| Cat.No. | Name | Information |
|---|---|---|
| M5696 | Hydroquinidine | Hydroquinidine (Dihydroquinidine, Hydroconchinine, Hydroconquinine, Dihydroquinine) is a multichannel blocker with anticancer and antimalarial activity, acting on Plasmodium with a median IC50 of 129 nM, and can be used in studies related to short QT and Brugada arrhythmia syndrome. |
| M5661 | Folic acid | Folic acid, a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA. |
| M5415 | Amphotericin B | Amphotericin B (AmB) is an amphipathic polyene antibiotic which permeabilizes ergosterol-containing membranes. |
| M5301 | (E)-Cardamonin | (E)-Cardamonin is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM, Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway. |
| M5206 | Tricin | Tricin is a natural flavonoid that is abundant in rice bran. Tricin inhibits HCMV replication by inhibiting CDK9. Tricin inhibits proliferation and invasion of C6 glioma cells by upregulating faK-targeted microrNA-7 expression. |
| M5158 | Tauroursodeoxycholic acid (Ursodoxicoltaurine) | Tauroursodeoxycholic acid (Ursodoxicoltaurine) is an endoplasmic reticulum stress inhibitor. It can significantly reduce the expression of apoptotic molecules such as caspase-3 and caspase-12. Tauroursodeoxycholate also suppresses ERK. It is a taurine conjugate of usodeoxycholic acid. |
| M5020 | Digitonin | Digitonin is a glycoside obtained from Digitalis purpurea, which could increase cell permeability by binding to cholesterol molecules and reduce tumor growth. |
| M4953 | Bafilomycin A1 | Bafilomycin A1 (BafA1) is a vacuolar H+-ATPase inhibitor with IC50 of 0.44 nM. |
| M4881 | Actinomycin D | Actinomycin D (Dactinomycin) is an antibiotic found in Streptomyces microsporum with antibacterial and anti-tumor effects. Actinomycin D is an inhibitor of RNA and protein synthesis. Actinomycin D can inhibit the protein synthesis of bacteria, directly bind to the guanine groups of single-stranded or double-stranded DNA in the transcriptional initiation complex, inhibit the activity of DNA-dependent RNA polymerase, and interfere with the transcription process of DNA, thereby inhibiting mRNA synthesis. Actinomycin D inhibits DNA repair with an IC50 value of 0.42 μM. |
| M4879 | Cycloheximide | Cycloheximide (Naramycin A) is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM. Cycloheximide binds to the E-site of the 60S subunit of the ribosome during the protein synthesis process in eukaryotic cells, blocking the ribosome translocation process mediated by eEF2 and preventing the synthesis of new proteins. Cycloheximide suppresses ferroptosis and inhibits autophagy. |
| M4798 | Tunicamycin | Tunicamycin is a mixture of nucleoside antibiotics that inhibits N-glycosylation and blocks GlcNAc phosphotransferase (GPT). |
| M4789 | Isoscopoletin | Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active ingredient in artemisia argyi leaves. Isoscopoletin showed significant inhibition of cell proliferation, with IC50 values of 4.0 μM and 1.6 μM against human CCRF-CEM leukemia cells and CEM/ADR5000 drug-resistant subline, respectively. Isoscopoletin (6-Hydroxy-7-methoxycoumarin) has the activity of inhibiting HBV replication. |
| M4779 | Cordycepin | Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative isolated from Cordyceps, inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts. |
| M4748 | Pectolinarigenin | Pectolinarigenin is a dual inhibitor of COX-2/5-LOX with anti-inflammatory activity. |
| M4718 | Dendrobine | Dendrobine is an alkaloid isolated from Dendrobium nobile. Dendrobine has antiviral activity against influenza A virus, IC50 values for A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2) were 3.39 μM, 2.16 μM and 5.32 μM, respectively. |
| M4691 | Lycorine hydrochloride | Lycorine hydrochloride is a natural alkaloid extracted from Amaryllidaceae (Amaryllidaceae) plants. It is a strong HCV inhibitor and melanoma angiogenesis inhibitor with anti-tumor activity. |
| M4678 | Fisetin | Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins. |
| M4647 | Phorbol 12-myristate 13-acetate | Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and protein kinase C (PKC) activator, increases the intracellular Ca2+ concentration ([Ca2+]i) in a dose-dependent manner, with an EC50 of 11.7 nM. |
| M4619 | Eupalinolide B | Eupalinolide B is a germacrane sesquiterpene isolated from Eupatorium lindleyanum. Eupalinolide B demonstrates potent cytotoxicity against A-549, BGC-823 and HL-60 tumour cell lines. |
| M4614 | Orientin | Orientin |
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