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Folic acid

Cat. No. M5661
Folic acid Structure
Synonym:

Folacin, Vitamin B9, Vitamin M, Pteroylglutamic acid, Folate

Size Price Availability Quantity
500mg USD 30  USD30 In stock
1g USD 40  USD40 In stock
5g USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Folic acid, a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA.

Chemical Information
Molecular Weight 441.40
Formula C19H19N7O6
CAS Number 59-30-3
Solubility (25°C) DMSO ≥ 25 mg/mL
1M NaOH 90 mg/mL
Storage 2-8°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hathairat Sawaengsri, et al. J Nutr Biochem. High Folic Acid Intake Reduces Natural Killer Cell Cytotoxicity in Aged Mice

[2] Patanwala I, et al. Am J Clin Nutr. Folic acid handling by the human gut: implications for food fortification and supplementation.

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Keywords: Folic acid, Folacin, Vitamin B9, Vitamin M, Pteroylglutamic acid, Folate supplier, Vitamin, inhibitors, activators


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