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Menaquinone-7

Cat. No. M55300
Menaquinone-7 Structure
Synonym:

Vitamin K2-7; Vitamin MK-7

Size Price Availability Quantity
5mg USD 100  USD100 In stock
10mg USD 140  USD140 In stock
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Quality Control & Documentation
Biological Activity

Menaquinone-7 (Vitamin K2-7) belongs to a class of K2-vitamin homologs (orally active), it is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 (Vitamin K2, MK-7) inhibits osteoclast bone resorption in vitro and stimulates bone formation in femoral tissue of aged female rats. Menaquinone-7 is also a pharmacological option for activating Gla matrix protein and intervening in the progression of calcific aortic stenosis (CAVS).

Chemical Information
Molecular Weight 649.0
Formula C46H64O2
CAS Number 2124-57-4
Solubility (25°C) DMSO 4 mg/mL
Storage -20°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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  Catalog
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Keywords: Menaquinone-7, Vitamin K2-7; Vitamin MK-7 supplier, Vitamin, inhibitors, activators


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