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Atocalcitol

Cat. No. M29867
Atocalcitol Structure
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Quality Control & Documentation
Biological Activity

Atocalcitol, a vitamin D3 analogue, is used in the study for psoriasis.

Chemical Information
Molecular Weight 494.71
Formula C32H46O4
CAS Number 302904-82-1
Form Solid
Solubility (25°C) DMSO 25 mg/mL (ultrasonic and warming and heat to 60°C)
Storage -20°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Roger N Haber, et al. Indian J Dermatol Venereol Leprol. Management of Darier disease: A review of the literature and update

[2] Priyadarshini Sahu, et al. Photodermatol Photoimmunol Photomed. Tacalcitol: a useful adjunct to narrow-band ultraviolet-B phototherapy in vitiligo

[3] Parul Aggarwal, et al. J Dermatolog Treat. Tacalcitol: A useful adjunct to narrow band ultraviolet B phototherapy in psoriasis

[4] P V Harrison. Hosp Med. Topical tacalcitol treatment for psoriasis

[5] D C Peters, et al. Drugs. Tacalcitol

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