VDR agonist 2

Cat. No. M43610

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Quality Control & Documentation

Purity:
COA
MSDS

Product Information

Biological Activity

VDR agonist 2 is a VDR (vitamin D receptor) agonist that can effectively inhibit TGF-β1-induced activation of hepatic stellate cells (HSC).

Chemical Information

Molecular Weight	366.37
Formula	C20H21F3O3
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m²)	0.007	0.025	0.15	0.05	0.02	0.5
K_m factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B K_m
	Animal A K_m

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Bálint Rehó et al. J Biol Chem. Agonist-controlled competition of RAR and VDR nuclear receptors for heterodimerization with RXR is manifested in their DNA binding

[2] Anna A Brożyna et al. Int J Mol Sci. Vitamin D Signaling in Psoriasis: Pathogenesis and Therapy

[3] Siqing Jiang et al. J Steroid Biochem Mol Biol. Vitamin D/VDR attenuate cisplatin-induced AKI by down-regulating NLRP3/Caspase-1/GSDMD pyroptosis pathway

[4] Zhaoxin Hu et al. Cell Death Dis. VDR activation attenuate cisplatin induced AKI by inhibiting ferroptosis

[5] Sylvia Christakos et al. Physiol Rev. Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects

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Signaling Pathways

VDR agonist 2

Quality Control & Documentation

Biological Activity

Chemical Information

Conversion of different model animals based on BSA (PMID: 27057123)

References

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