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Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active ingredient in artemisia argyi leaves. Isoscopoletin showed significant inhibition of cell proliferation, with IC50 values of 4.0 μM and 1.6 μM against human CCRF-CEM leukemia cells and CEM/ADR5000 drug-resistant subline, respectively. Isoscopoletin (6-Hydroxy-7-methoxycoumarin) has the activity of inhibiting HBV replication.
Food Chem Toxicol. 2023 Jan 12;173:113609.
Inhibition of ATF4-mediated elevation of both autophagy and AKT/mTOR was involved in antitumorigenic activity of curcumin
Isoscopoletin purchased from AbMole
| Molecular Weight | 192.17 |
| Formula | C10H8O4 |
| CAS Number | 776-86-3 |
| Form | Solid |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Houaria Bendjedou, et al. A new ionone derivative from Lycium intricatum Boiss. (Solanaceae)
[3] Risto O Juvonen, et al. Metabolism of Scoparone in Experimental Animals and Humans
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