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Amphotericin B

Cat. No. M5415
Amphotericin B  Structure
Synonym:

NSC 527017

Size Price Availability Quantity
100mg USD 50  USD50 In stock
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Quality Control & Documentation
  • Purity: Potency >750 ug/mg, cell culture grade
  • COA
  • MSDS
  • H-NMR
Biological Activity

Amphotericin B (AmB) is an amphipathic polyene antibiotic which permeabilizes ergosterol-containing membranes.

Product Citations
Chemical Information
Molecular Weight 924.08
Formula C47H73NO17
CAS Number 1397-89-3
Solubility (25°C) 22 mg/mL in DMSO
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Azanza JR, et al. Rev Esp Quimioter. Liposomal formulations of amphotericin B: differences according to the scientific evidence.

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Keywords: Amphotericin B , NSC 527017 supplier, Antibiotic, inhibitors, activators


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