Free shipping on all orders over $ 500

Tussilagone

Cat. No. M4791
Tussilagone Structure
Size Price Availability Quantity
5mg USD 135  USD135 In stock
10mg USD 225  USD225 In stock
20mg USD 380  USD380 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Tussilagone is a major active component in Tussilago farfara, has anti-inflammatory effect. Tussilagone inhibits the inflammatory response and improves survival in cecal ligation and puncture (CLP)-induced septic mice.

Chemical Information
Molecular Weight 390.51
Formula C23H34O5
CAS Number 104012-37-5
Solubility (25°C) DMSO
Storage 2-8°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jing Zhou, et al. Antiplatelet Activity of Tussilagone via Inhibition of the GPVI Downstream Signaling Pathway in Platelets

[2] Ga-Hee Ryoo, et al. Tussilagone promotes osteoclast apoptosis and prevents estrogen deficiency-induced osteoporosis in mice

[3] Sang-Hyeon Nam, et al. Tussilagone Reduces Tumorigenesis by Diminishing Inflammation in Experimental Colitis-Associated Colon Cancer

[4] Chaoying Jin, et al. Tussilagone inhibits allergic responses in OVA-induced allergic rhinitis guinea pigs and IgE-stimulated RBL-2H3 cells

[5] Jia Li, et al. Tussilagone Suppresses Angiogenesis by Inhibiting the VEGFR2 Signaling Pathway

Related Immunology/Inflammation Products
BK50164

BK50164 is a potent CD73 inhibitor with an IC50 value of 13.089 µM.

CCT374705

CCT374705 is an orally active BCL6 inhibitor with potent antiproliferative effects in vitro.

Mycophenolate Sodium

Mycophenolate Sodium is a Mycophenolic acid precursor, as well as an inhibitor of T-lymphocyte proliferation and an inhibitor of inosine monophosphate dehydrogenase (IMPDH).

Efgartigimod

Efgartigimod (ARGX-113) is a human IgG1 antibody Fc-derived fragment and an Fc receptor antagonist that can be used in studies related to autoimmune diseases such as myasthenia gravis (MG), primary immune thrombocytopenia (ITP), and others.

DiaPep277

DiaPep277 is a peptide containing 24 amino acids based on residues 437 to 460 of Heat Shock Protein 60 (HSP60) for studies related to the immune system in type 1 diabetes.

  Catalog
Abmole Inhibitor Catalog




Keywords: Tussilagone supplier, Immunology/Inflammation, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.