About 31 results found for searched term "SI-2 hydrochloride" (0.091 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1989 | CHIR-99021 HCl | GSK-3 |
| Laduviglusib hydrochloride; CHIR-99021 hydrochloride | ||
| CHIR-99021 HCl (Laduviglusib; CT99021) is a hydrochloride of CHIR-99021, with IC50 of 10 nM and 6.7 nM for GSK-3α and GSK-3β, respectively. | ||
| M6594 | CHIR 99021 trihydrochloride | GSK-3 |
| Laduviglusib trihydrochloride; CT99021 trihydrochloride | ||
| Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. | ||
| M58108 | SI-2 hydrochloride | Src-bcr-Abl |
| EPH 116 hydrochloride | ||
| SI-2 hydrochloride is a highly promising SRC-3 inhibitor (PPI) with acceptable oral availability, with IC50 values of 3-20 nM for breast cancer cell death. | ||
| M2327 | Daunorubicin hydrochloride | DNA/RNA Synthesis |
| Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride | ||
| Daunorubicin (Daunomycin) HCl is a topoisomerase II inhibitor, inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. | ||
| M2593 | Siramesine hydrochloride | Sigma Receptor |
| Lu 28-179 | ||
| Siramesine (Lu 28-179) hydrochloride is an effective sigma-2 receptor agonist. Siramesine has a nanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and is 140 times more selective for sigma-2 receptors (IC50=17 nM). Siramesine has xC-system inhibitory activity associated with iron death. | ||
| M7481 | W-7 hydrochloride | CaMK |
| W7 hydrochloride | ||
| W-7 Hydrochloride is a selective calmodulin antagonist. W-7 Hydrochloride inhibits Ca2+ -calmodulin-dependent phosphodiesterase and Myosin light chain kinase. The IC50 values were 28 μM and 51 μM, respectively. W-7 Hydrochloride can induce apoptosis and has anti-cancer activity. | ||
| M8038 | CP-154526 hydrochloride | CRFR |
| CP-154526 hydrochloride is a selective, non-peptide antagonist of corticotropin releasing factor receptors (CRF1) with a Ki of 2.7 nM. CP 154526 hydrochloride shows selective for CRF1 over CRF2 (Ki = >10 μM). | ||
| M11225 | FTI-277 hydrochloride | Farnesyl Transferase |
| Fti-277 Hydrochloride, an FTase inhibitor of Farnici transferase, is a highly effective Ras CAAX peptide analog that inhibits H-RAS and K-RAS signal transduction. Fti-277 hydrochloride inhibits hepatitis delta virus (HDV) infection. | ||
| M9298 | AX-024 hydrochloride | Immunology/Inflammation |
| AX-024 HCl | ||
| Ax-024 Hydrochloride is orally available, the first tCR-NCK interaction inhibitor that selectively inhibits TCR-induced T cell activation with an IC50 value of 1 nM. Ax-024 Hydrochloride regulates cellular signaling by targeting the SH3 domain. Ax-024 Hydrochloride has the characteristics of low toxicity, high efficiency and high selectivity. | ||
| M10599 | PF-543 HCl | SPHK |
| PF-543 HCl; PF543 hydrochloride | ||
| PF-543 hydrochloride is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 hydrochloride is >100-fold selectivity for SPHK1 over SPHK2. | ||
| M10688 | TAK-659 hydrochloride | Syk |
| TAK-659 hydrochloride is a highly selective, reversible, orally potent dual inhibitor of SYK/FLT3 that acts on SYK and FLT3 IC50 The values are 3.2 nM and 4.6 nM, respectively. TAK-659 hydrochloride induces tumor cell death without acting on non-tumor cells, with potential to study chronic lymphocytic leukemia (CLL). | ||
| M14173 | GW806742X hydrochloride | Necroptosis |
| GW806742X hydrochloride is an ATP mimetic and potent inhibitor of MLKL and necroptosis, slowing down MLKL membrane translocation and binding to the MLKL pseudokinase domain with a Kd value of 9.3 μM. GW806742X hydrochloride has anti-VEGFR2 activity (IC50=2 nM). GW806742X hydrochloride has anti-VEGFR2 activity (IC50=2 nM). | ||
| M14851 | Buparlisib Hydrochloride | PI3K |
| BKM120 Hydrochloride; NVP-BKM120 Hydrochloride | ||
| Buparlisib Hydrochloride (BKM120 Hydrochloride) is a pan-class I PI3K inhibitor, with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/p110β/p110δ/p110γ, respectively. | ||
| M14858 | Umbralisib hydrochloride | PI3K |
| TGR-1202 hydrochloride; RP5264 hydrochloride | ||
| Umbralisib hydrochloride (TGR-1202 hydrochloride) is a novel PI3Kδ inhibitor, with IC50 and EC50 of 22.2 nM and 24.3 nM, respectively; Umbralisib hydrochloride (TGR-1202 hydrochloride) is also active against CK1ε, with an EC50 value of 6.0 μM. | ||
| M20837 | Simufilam dihydrochloride | Others |
| PTI-125 dihydrochloride | ||
| Simufilam (PTI-125) Dihydrochloride is a small molecule modulator that preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies. | ||
| M21510 | Telaglenastat hydrochloride | Others |
| CB-839 hydrochloride | ||
| Telaglenastat (CB-839) hydrochloride is a pioneering (first-in-class), selective, reversible, orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat hydrochloride has IC50 values of 23 nM and 28 nM for endogenous glutaminase in the kidney and brain of mice, respectively. Telaglenastat hydrochloride also induces autophagy and has strong antitumor activity. | ||
| M25555 | BIIE-0246 hydrochloride | Neuropeptide Receptor |
| AR-H 053591 hydrochloride | ||
| BIIE-0246 hydrochloride (AR-H 053591 hydrochloride) is a potent and selective NPY2R (neuropeptide Y receptor 2) antagonist with an IC50 value of 15 nM for rat [125I]PYY3-36. BIIE-0246 hydrochloride decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated. BIIE-0246 hydrochloride reduces albuminuria in ADR nephropathy. | ||
| M27705 | Dagrocorat hydrochloride | GCR |
| PF-00251802 hydrochloride | ||
| Dagrocorat (PF-00251802) hydrochloride is an orally active and selective high-affinity partial agonist of the glucocorticoid receptor. Dagrocorat hydrochloride is also a time-dependent reversible inhibitor of CYP3A (IC50=1.3 μM in human liver microsomes) and CYP2D6 (Ki=0.57 μM in human liver microsomes). Dagrocorat hydrochloride can be used for the research of rheumatoid arthritis. | ||
| M27717 | SB 242084 dihydrochloride | 5-HT Receptor |
| SB 242084 dihydrochloride is a selective, competitive and high-affinity (pKi=9.0) 5-HT2C receptor antagonist (crosses the blood-brain barrier). SB 242084 dihydrochloride increases basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and dopamine release in the vomeronasal nucleus. SB 242084 dihydrochloride also increases mitochondrial gene expression and oxidative metabolism via 5-HT2A receptor. SB 242084 dihydrochloride has good research potential in the negative symptoms of anxiety, depression and schizophrenia, as well as in acute organ damage. | ||
| M27863 | DC07090 dihydrochloride | Anti-infection |
| DC07090 dihydrochloride is a low toxicity, potent, reversible and competitive non-peptidyl human enterovirus 71 3C protease inhibitor with an IC50 and a Ki value for 21.72 μM and 23.29 μM. DC07090 dihydrochloride could also inhibit coxsackievirus A16 (CVA16) replication with an EC50 value of 27.76 μM. | ||
| M28096 | S1RA hydrochloride | Sigma Receptor |
| E-52862 hydrochloride | ||
| S1RA (E-52862) hydrochloride is an orally active and selective sigma-1 receptor (σ1R) antagonist with a Ki value of 17 nM. S1RA hydrochloride shows good selectivity against σ2R (Ki >1000 nM). S1RA hydrochloride is a human 5-HT2B receptor antagonist with an IC50 value of 4.7 μM. S1RA hydrochloride inhibits neuropathic pain and activity-induced spinal sensitization. | ||
| M28109 | PF-3758309 hydrochloride | PAK |
| PF-03758309 hydrochloride | ||
| PF-3758309 (PF-03758309) hydrochloride is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 (Kd= 2.7 nM; Ki=18.7 nM). PF-3758309 hydrochloride has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage-independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition of proliferation. | ||
| M28185 | Azvudine hydrochloride | Reverse Transcriptase |
| RO-0622 hydrochloride; FNC hydrochloride | ||
| Azvudine (RO-0622) hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine hydrochloride exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine hydrochloride inhibits NRTI-resistant viral strains. | ||
| M28582 | Sibenadet hydrochloride | Dopamine Receptor |
| AR-C68397AA | ||
| Sibenadet hydrochloride (AR-C68397AA) is a dual D2 dopamine receptor, beta2-adrenoceptor agonist with bronchodilator activity. Investigation in animal models of key chronic obstructive pulmonary disease (COPD) symptoms has demonstrated that Sibenadet hydrochloride effectively inhibits sensory nerve activity, thereby reducing reflex cough, mucus production and tachypnoea. | ||
| M28834 | L-hydroxylysine dihydrochloride | Metabolite/Endogenous Metabolite |
| (2S,5R)-5-Hydroxylysine dihydrochloride | ||
| L-hydroxylysine dihydrochloride ((2S,5R)-5-Hydroxylysine dihydrochloride), an amino acid, is exclusive to collagen protein, which is formed by posttranslational hydroxylation of some lysine residues. | ||
| M29002 | SLM6031434 hydrochloride | SPHK |
| SLM6031434 hydrochloride is a highly selective sphingosine kinase 2 (SphK2) inhibitor with Kis of 0.4 μM, 0.5 μM, >20 μM, 22 μM for mSphK2, rSphK2, mSphK1 and rSphK1, respectively. SLM6031434 hydrochloride decrease Sphingosine 1-phosphate (S1P) levels in U937 monocytic leukemia cells. SLM6031434 hydrochloride has the potential for renal fibrosis research. | ||
| M29010 | Sisunatovir hydrochloride | RSV |
| RV521 hydrochloride | ||
| Sisunatovir (RV521) hydrochloride, an orally available inhibitor of the RSV fusion (RSV-F) protein, exhibits potent efficacy against a panel of clinical isolates of RSV-A and RSV-B viruses, with IC50s of 1.4 nM and 1.0 nM, respectively. | ||
| M29244 | UNC9994 hydrochloride | Dopamine Receptor |
| UNC9994 hydrochloride is a functionally selective, β-arrestin–biased dopamine D2 receptor (D2R) agonist that selectively activates β-arrestin recruitment and signaling. UNC9994 hydrochloride shows a binding affinity with a Ki of 79 nM for D2R. UNC9994 hydrochloride is also an antagonist of Gi-regulated cAMP production and partial agonist for D2R/β-arrestin-2 interactions. UNC9994 hydrochloride shows antipsychotic-like activity. | ||
| M29379 | Galidesivir hydrochloride | DNA/RNA Synthesis |
| BCX4430 hydrochloride; Immucillin-A hydrochloride | ||
| Galidesivir (BCX4430) hydrochloride, an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir hydrochloride is active in vitro against many RNA viral pathogens, including the filoviruses and emerging infectious agents such as MERS-CoV, SARS-CoV, and SARS-CoV-2. Galidesivir hydrochloride inhibits some negative-sense RNA viruses with EC50s ranging from ~3 to ~68 μM. | ||
| M29414 | Taniborbactam hydrochloride | Antibiotic |
| VNRX-5133 hydrochloride | ||
| Taniborbactam hydrochloride (VNRX-5133 hydrochloride) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam hydrochloride has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam hydrochloride is against Gram-negative bacteria. | ||
| M30244 | Carubicin hydrochloride | Apoptosis |
| Carminomycin hydrochloride; Carminomicin I hydrochloride | ||
| Carubicin hydrochloride is a microbially-derived compound. Carubicin hydrochloride is an effective inhibitor of VHL-defective (VHL−/−) CCRCC cell proliferation. Carubicin hydrochloride also induces apoptosis by a mechanism independent of p53 or hypoxia-inducible factor HIF2. Carubicin hydrochloride has the potential for the research of cancer diseases. | ||
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