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S1RA (E-52862) hydrochloride is an orally active and selective sigma-1 receptor (σ1R) antagonist with a Ki value of 17 nM. S1RA hydrochloride shows good selectivity against σ2R (Ki >1000 nM). S1RA hydrochloride is a human 5-HT2B receptor antagonist with an IC50 value of 4.7 μM. S1RA hydrochloride inhibits neuropathic pain and activity-induced spinal sensitization.
| Molecular Weight | 373.88 |
| Formula | C20H24ClN3O2 |
| CAS Number | 1265917-14-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL (ultrasonic) Water 16.67 mg/mL (ultrasonic) |
| Storage | 4°C, dry, sealed |
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