| Cat.No. | Name | Information |
|---|---|---|
| M10723 | Ditolylguanidine | Ditolylguanidine (1,3-Di-o-tolylguanidine) is a sigma receptor (σ1/σ2 receptor) agonist. |
| M10722 | PRE-084 hydrochloride | PRE-084 hydrochloride is a highly affinity selective σ1 agonist with an IC50 value of 44 nM in the sigma receptor detection. |
| M10721 | Dimemorfan phosphate | Dimemorfan phosphate is a potent agonist of sigma 1 receptor that is effective in suppressing cough. |
| M6496 | BD 1063 dihydrochloride | BD 1063 dihydrochloride is a selective σ1 ligand, putative antagonist. |
| M6495 | BD 1047 dihydrobromide | BD 1047 dihydrobromide is a σ 1 selective antagonist. |
| M6346 | 4-PPBP maleate | 4-PPBP maleate is a specific σ ligand, NMDA antagonist. |
| M6344 | 4-IBP | 4-IBP is a σ ligand, σ 1> σ 2. |
| M6203 | Blarcamesine hydrochloride | Blarcamesine hydrochloride is a Sigma-1 Receptor agonist with an IC50 of 860 nM. |
| M2991 | SA 4503 dihydrochloride | SA 4503 is a novel and selective opioid sigma1 receptor agonist with IC50 of 17.4 nM. |
| M2924 | Pentoxyverine Citrate | Pentoxyverine citrate is an orally active sigma-1 receptor agonist with Ki values of 41 nM for σ1, 894 nM for σ2, and 75 nM for σ1 in guinea pig brain membranes.Pentoxyverine citrate is also a muscarinic antagonist. |
| M2596 | S1RA | S1RA (E-52862) is a potent and selective sigma-1 receptor (σ1R, Ki=17 nM), which showes good selectivity against σ2R (Ki > 1000 nM). |
| M2593 | Siramesine hydrochloride | Siramesine (Lu 28-179) hydrochloride is an effective sigma-2 receptor agonist. Siramesine has a nanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and is 140 times more selective for sigma-2 receptors (IC50=17 nM). Siramesine has xC-system inhibitory activity associated with iron death. |
| M2592 | Siramesine | Siramesine (Lu 28-179) is a potent sigma-2 receptor agonist. Siramesine has a subnanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17 nM). Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. |
| M50236 | ANAVEX 3-71 | ANAVEX 3-71 is an orally active SIGMAR1 receptor agonist and M1-positive variant modulator for studies related to schizophrenia. |
| M45323 | Blarcamesine | Blarcamesine is a Sigma-1 receptor agonist and muscarinic receptor modulator with neuroprotective and antidepressant activity. In addition, Blarcamesine ameliorates neurological impairment in a mouse model of Rett syndrome. |
| M42707 | AB10 | AB10 is a selective S1R antagonist. |
| M42706 | WLB-89462 | WLB-89462 is a selective σ2 receptor ligand (Ki: 13 nM). |
| M42705 | Siramesine fumarate | Siramesine (Lu 28-179) fumarate is a potent sigma-2 receptor agonist. |
| M42704 | Sigma-1 receptor antagonist 5 | Sigma-1 receptor antagonist 5 and histamine H3 (hH3R, Ki=7.7 nM, IC50=215 nM). |
| M42703 | AB21 | AB21 is a potent and selective S1R antagonist with Kis of 13, 102 nM for S1R and S2R. |
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