| Cat.No. | Name | Information |
|---|---|---|
| M14060 | CT1812 | CT1812 (Sigma-2 receptor antagonist 1) is an orally active and brain penetrant sigma-2 (σ-2) receptor antagonist with a Ki of 8.5 nM. |
| M10723 | Ditolylguanidine | Ditolylguanidine (1,3-Di-o-tolylguanidine) is a sigma receptor (σ1/σ2 receptor) agonist. |
| M10722 | PRE-084 hydrochloride | PRE-084 hydrochloride is a highly affinity selective σ1 agonist with an IC50 value of 44 nM in the sigma receptor detection. |
| M10721 | Dimemorfan phosphate | Dimemorfan phosphate is a potent agonist of sigma 1 receptor that is effective in suppressing cough. |
| M6496 | BD 1063 dihydrochloride | BD 1063 dihydrochloride is a selective σ1 ligand, putative antagonist. |
| M6495 | BD-1047 dihydrobromide | BD-1047 dihydrobromide is a σ1 selective antagonist. |
| M6346 | 4-PPBP maleate | 4-PPBP maleate is a specific σ ligand, NMDA antagonist. |
| M6344 | 4-IBP | 4-IBP is a σ ligand, σ 1> σ 2. |
| M6203 | Blarcamesine hydrochloride | Blarcamesine hydrochloride is a Sigma-1 Receptor agonist with an IC50 of 860 nM. |
| M2991 | SA 4503 dihydrochloride | SA 4503 is a novel and selective opioid sigma1 receptor agonist with IC50 of 17.4 nM. |
| M2924 | Pentoxyverine Citrate | Pentoxyverine citrate is an orally active sigma-1 receptor agonist with Ki values of 41 nM for σ1, 894 nM for σ2, and 75 nM for σ1 in guinea pig brain membranes.Pentoxyverine citrate is also a muscarinic antagonist. |
| M2596 | S1RA | S1RA (E-52862) is a potent and selective sigma-1 receptor (σ1R, Ki=17 nM), which showes good selectivity against σ2R (Ki > 1000 nM). |
| M2593 | Siramesine hydrochloride | Siramesine (Lu 28-179) hydrochloride is an effective sigma-2 receptor agonist. Siramesine has a nanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and is 140 times more selective for sigma-2 receptors (IC50=17 nM). Siramesine has xC-system inhibitory activity associated with iron death. |
| M2592 | Siramesine | Siramesine (Lu 28-179) is a potent sigma-2 receptor agonist. Siramesine has a subnanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17 nM). Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. |
| M56826 | IPAG | IPAG is a potent sigma-1 receptor antagonist with a pKi of 4.3. |
| M56825 | PB28 dihydrochloride | PB28 dihydrochloride, a cyclohexylpiperazine derivative, is a high affinity and selective sigma 2 (σ2) receptor agonist with a Ki of 0.68 nM. |
| M56824 | (±)-PPCC hemioxalate | (±)-PPCC hemioxalate is a compound that has the ability to regulate the activity of the sigma-1 receptor. |
| M56823 | (+)-Igmesine hydrochloride | (+)-Igmesine hydrochloride (JO1784) is an orally active and selective σ receptor ligand with neuroprotective and anti-amnesic activities. |
| M50236 | ANAVEX 3-71 | ANAVEX 3-71 is an orally active SIGMAR1 receptor agonist and M1-positive variant modulator for studies related to schizophrenia. |
| M45323 | Blarcamesine | Blarcamesine is a Sigma-1 receptor agonist and muscarinic receptor modulator with neuroprotective and antidepressant activity. In addition, Blarcamesine ameliorates neurological impairment in a mouse model of Rett syndrome. |
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