| Cat.No. | Name | Information |
|---|---|---|
| M28136 | E1R | E1R is a positive allosteric modulator of sigma-1 receptors (Sig1R PAM) with cognition-enhancing activity. |
| M28096 | S1RA hydrochloride | S1RA (E-52862) hydrochloride is an orally active and selective sigma-1 receptor (σ1R) antagonist with a Ki value of 17 nM. S1RA hydrochloride shows good selectivity against σ2R (Ki >1000 nM). S1RA hydrochloride is a human 5-HT2B receptor antagonist with an IC50 value of 4.7 μM. S1RA hydrochloride inhibits neuropathic pain and activity-induced spinal sensitization. |
| M27937 | σ1 Receptor antagonist-1 | σ1 Receptor antagonist-1 is a highly potent and selective sigma 1 receptor antagonist (pKi=10.28). σ1 Receptor antagonist-1 inhibits cell growth, arrests cell cycle at G0/G1 phase and induces apoptosis of MCF-7/ADR cells. |
| M27813 | CM398 | CM398 is a highly selective, orally active sigma-2 receptor ligand (Ki=0.43 nM), with high sigma-1/sigma-2 selectivity rato (1000-fold). CM398 shows notable affinity for dopamine (Ki=32.90 nM) and serotonin transporters (Ki=244.2 nM). CM398 shows promising anti-inflammatory analgesic effects in the formalin model of inflammatory pain in mice. |
| M22051 | Cutamesine | Cutamesine (SA4503; AGY-94806) is a selective sigma 1 receptor(σ1R) agonist, with IC50 of 17.4 nM for the sigma 1 receptor. |
| M7903 | Metaphit methanesulfonate salt | Metaphit methanesulfonate salt is an irreversible, non-competitive antagonist at the phencyclidine site on the NMDA receptor; sigma receptor irreversible, competitive antagonist. |
| M7669 | BMY-14802 | BMY-14802 is a potent and selective sigma-1 (σ1) receptor antagonist with an IC50 value of approximately 100 nM. |
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