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σ1 Receptor antagonist-1 

Cat. No. M27937

All AbMole products are for research use only, cannot be used for human consumption.

σ1 Receptor antagonist-1  Structure

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Biological Activity

σ1 Receptor antagonist-1 is a highly potent and selective sigma 1 receptor antagonist (pKi=10.28). σ1 Receptor antagonist-1 inhibits cell growth, arrests cell cycle at G0/G1 phase and induces apoptosis of MCF-7/ADR cells.

Chemical Information
Molecular Weight 337.48
Formula C21H23NOS
CAS Number 1204401-49-9
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Preeti Borde, et al. Cancer Gene Ther. An investigation of Sigma-1 receptor expression and ligand-induced endoplasmic reticulum stress in breast cancer

[2] Carlo Cifani, et al. ACS Chem Neurosci. Novel Highly Potent and Selective Sigma1 Receptor Antagonists Effectively Block the Binge Eating Episode in Female Rats

[3] Fabio Del Bello, et al. ACS Chem Neurosci. Investigation of the Role of Chirality in the Interaction with σ Receptors and Effect on Binge Eating Episode of a Potent σ1 Antagonist Analogue of Spipethiane

[4] Shigeyuki Chaki, et al. J Pharmacol Exp Ther. Anxiolytic-like and antidepressant-like activities of MCL0129 (1-[(S)-2-(4-fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine), a novel and potent nonpeptide antagonist of the melanocortin-4 receptor

[5] A Bhardwaj, et al. Stroke. Potent sigma1-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine modulates basal and N-methyl-D-aspartate-evoked nitric oxide production in vivo

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Keywords: σ1 Receptor antagonist-1  supplier, Sigma Receptor, inhibitors, activators

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