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S1RA is a potent and selective sigma-1 receptor (σ1R, Ki=17 nM), which showes good selectivity against σ2R (Ki > 1000 nM). S1RA dose-dependently inhibites formalin-induced nociception (both phases), capsaicin-induced mechanical hypersensitivity and sciatic nerve injury-induced mechanical and thermal hypersensitivity.
| Molecular Weight | 337.42 |
| Formula | C20H23N3O2 |
| CAS Number | 878141-96-9 |
| Solubility (25°C) | DMSO 30 mg/mL (ultrasonic and warming and heat to 60°C) 1M HCl : 40 mg/mL (ultrasonic and adjust pH to 1 with HCl) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Sigma Receptor Products |
|---|
| IPAG
IPAG is a potent sigma-1 receptor antagonist with a pKi of 4.3. |
| PB28 dihydrochloride
PB28 dihydrochloride, a cyclohexylpiperazine derivative, is a high affinity and selective sigma 2 (σ2) receptor agonist with a Ki of 0.68 nM. |
| (±)-PPCC hemioxalate
(±)-PPCC hemioxalate is a compound that has the ability to regulate the activity of the sigma-1 receptor. |
| (+)-Igmesine hydrochloride
(+)-Igmesine hydrochloride (JO1784) is an orally active and selective σ receptor ligand with neuroprotective and anti-amnesic activities. |
| ANAVEX 3-71
ANAVEX 3-71 is an orally active SIGMAR1 receptor agonist and M1-positive variant modulator for studies related to schizophrenia. |
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