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Cat. No. M2592
Siramesine Structure

Lu 28-179

Size Price Availability Quantity
2mg USD 165  USD165 In stock
5mg USD 245  USD245 In stock
10mg USD 380  USD380 In stock
50mg USD 920  USD920 In stock
100mg USD 1440  USD1440 In stock
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Quality Control & Documentation
Biological Activity

Siramesine(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo. Siramesine can induce cell death in transformed cells through a mechanism including lysosomal destabilization. 

In vivo, siramesine treatment of mice caused a depletion of the MC populations of the peritoneum and skin.

Chemical Information
Molecular Weight 454.58
Formula C30H31FN2O
CAS Number 147817-50-3
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Spirkoski J,et al. Biochem Pharmacol. Mast cell apoptosis induced by siramesine, a sigma-2 receptor agonist.

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Keywords: Siramesine, Lu 28-179 supplier, Sigma Receptor, inhibitors, activators

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