About 3 results found for searched term "Siramesine" (0.136 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2593 | Siramesine hydrochloride | Sigma Receptor |
| Lu 28-179 | ||
| Siramesine (Lu 28-179) hydrochloride is an effective sigma-2 receptor agonist. Siramesine has a nanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and is 140 times more selective for sigma-2 receptors (IC50=17 nM). Siramesine has xC-system inhibitory activity associated with iron death. | ||
| M2592 | Siramesine | Sigma Receptor |
| Lu 28-179 | ||
| Siramesine (Lu 28-179) is a potent sigma-2 receptor agonist. Siramesine has a subnanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17 nM). Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. | ||
| M42705 | Siramesine fumarate | Sigma Receptor |
| Siramesine (Lu 28-179) fumarate is a potent sigma-2 receptor agonist. | ||
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