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Blarcamesine hydrochloride is a Sigma-1 Receptor agonist with an IC50 of 860 nM.
The pre-administration of Blarcamesine leads to a dose-dependent attenuation of the scopolamine induced alternation deficit, significant at 1 and 3 mg/kg. The pre-treatment with Blarcamesine hydrochloride attenuates the impairments of step-through latency, dose dependently and significantly at doses higher than 0.3 mg/kg.
The Blarcamesine hydrochloride treatment dose-dependently blocks the recognition memory deficit, with a significant effect measured at 1 mg/kg. One day after injections, the significant Aβ25-35-induced decrease in Akt phosphorylation is significantly attenuated by Blarcamesine hydrochloride at 0.1 and 1 mg/kg dose. Seven days after injections, Blarcamesine hydrochloride attenuates the decrease in Ser9 phosphorylation induced by the peptide at 0.3 and 1 mg/kg.
The Blarcamesine hydrochloride treatment dose-dependently prevents the Aβ25-35-induced increase in Aβ1-42 content, with a significant effect at the highest dose tested.
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| Preparation method | |
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| Animal Experiment | |
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| Animal models | Male mice |
| Formulation | physiological saline solution |
| Dosages | 100 μL/20 g |
| Administration | i.c.v. |
| Molecular Weight | 317.85 |
| Formula | C19H23NO.HCl |
| CAS Number | 195615-84-0 |
| Solubility (25°C) | Water 100 mg/mL DMSO 25 mg/mL |
| Storage | 4°C, dry, sealed |
[2] Collina S, et al. Expert Opin Ther Pat. Sigma receptor modulators: a patent review.
| Related Sigma Receptor Products |
|---|
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IPAG is a potent sigma-1 receptor antagonist with a pKi of 4.3. |
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PB28 dihydrochloride, a cyclohexylpiperazine derivative, is a high affinity and selective sigma 2 (σ2) receptor agonist with a Ki of 0.68 nM. |
| (±)-PPCC hemioxalate
(±)-PPCC hemioxalate is a compound that has the ability to regulate the activity of the sigma-1 receptor. |
| (+)-Igmesine hydrochloride
(+)-Igmesine hydrochloride (JO1784) is an orally active and selective σ receptor ligand with neuroprotective and anti-amnesic activities. |
| ANAVEX 3-71
ANAVEX 3-71 is an orally active SIGMAR1 receptor agonist and M1-positive variant modulator for studies related to schizophrenia. |
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