Certificate of Analysis
| Product Name: | S1RA hydrochloride |
| Catalog Number: | M28096 |
| CAS Number: | 1265917-14-3 |
Physical and Chemical Properties
| Formula: | C20H24ClN3O2 |
| Molecular Weight: | 373.88 |
| Form: | Solid |
| Solubility: | DMSO 100 mg/mL (ultrasonic); Water 16.67 mg/mL (ultrasonic) |
| Storage: | 4°C, dry, sealed |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | ≥99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | S1RA (E-52862) hydrochloride is an orally active and selective sigma-1 receptor (σ1R) antagonist with a Ki value of 17 nM. S1RA hydrochloride shows good selectivity against σ2R (Ki >1000 nM). S1RA hydrochloride is a human 5-HT2B receptor antagonist with an IC50 value of 4.7 μM. S1RA hydrochloride inhibits neuropathic pain and activity-induced spinal sensitization. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |