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Carubicin hydrochloride is a microbially-derived compound. Carubicin hydrochloride is an effective inhibitor of VHL-defective (VHL−/−) CCRCC cell proliferation. Carubicin hydrochloride also induces apoptosis by a mechanism independent of p53 or hypoxia-inducible factor HIF2. Carubicin hydrochloride has the potential for the research of cancer diseases.
| Molecular Weight | 549.95 |
| Formula | C26H28ClNO10 |
| CAS Number | 52794-97-5 |
| Form | Solid |
| Solubility (25°C) | DMSO 62.5 mg/mL (ultrasonic) |
| Storage | 4°C, dry, sealed |
[1] C Monneret. Eur J Med Chem. Recent developments in the field of antitumour anthracyclines
[2] M Ogawa, et al. Gan To Kagaku Ryoho. [New anthracyclines]
[3] R C Young, et al. N Engl J Med. The anthracycline antineoplastic drugs
[5] F M Muggia, et al. Crit Rev Oncol Hematol. New anthracycline antitumor antibiotics
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