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CHIR 99021 trihydrochloride

Cat. No. M6594
CHIR 99021 trihydrochloride Structure
Synonym:

CT99021 trihydrochloride;Laduviglusib trihydrochloride

Size Price Availability Quantity
10mg USD 100  USD100 In stock
50mg USD 260  USD260 In stock
100mg USD 520  USD520 In stock
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Quality Control & Documentation
Biological Activity

CHIR 99021 trihydrochloride is a hydrochloride salt of CHIR 99021, a highly selective GSK-3 inhibitor.

Chemical Information
Molecular Weight 574.72
Formula C22H18Cl2N8.3HCl
CAS Number 1782235-14-6
Solubility (25°C) DMSO 28.74 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] O'Brien, et al. J Pharmacol Exp Ther. A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain.

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Keywords: CHIR 99021 trihydrochloride, CT99021 trihydrochloride;Laduviglusib trihydrochloride supplier, GSK-3, inhibitors, activators


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