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GSK-3 Glycogen synthase kinase 3

Inhibitors

Cat.No.  Name Information
M1692 CHIR-99021 CHIR-99021 (CT99021) is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively.
M2304 TWS119 TWS119 is a GSK-3β inhibitor with IC50 of 30 nM.
M1989 CHIR-99021 HCl CHIR-99021 HCl (CT99021) is a hydrochloride of CHIR-99021, with IC50 of 10 nM and 6.7 nM for GSK-3α and GSK-3β, respectively.
M21232 MeBIO MeBIO, an analog of 6-bromoindirubin-3'-oxime, has been suggested to possess the structural basis for a potent and selective inhibitor of glycogen synthase kinase-3 (GSK3) and cyclin-dependent kinases. MeBIO displays minimal activity against CDK1/Cyclin B, GSK-3, and CDK5/p25 (IC50 values are 92.0, 44-100 and >100 μM respectively). MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist.
M20836 Indirubin-3′-oxime Indirubin-3′-oxime (IDR3O, I3O) is an indirubin analogue that shows favorable inhibitory activity targeting GSK-3β and CDKs. Indirubin-3′-oxime also inhibits JNKs with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM for JNK1, JNK2, and JNK3, respectively. Indirubin-3′-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity.
M20731 9-ing-41 9-ING-41 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with antitumor activity. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.
M20489 5-Bromoindole 5-bromoindole is an important pharmaceutical chemical intermediate and a potential inhibitor of glycogen synthase kinase 3 (GSK-3).
M20324 WAY-333184 WAY-333184 is a inhibitor of glycogen synthase kinase-3b (GSK-3b).
M20308 WAY-333175 WAY-333175 is a inhibitor of glycogen synthase kinase-3b (GSK-3b).
M20239 WAY-634931 WAY-634931 is a inhibitor of GSK3 kinases
M20222 WAY-624687 WAY-624687 is a GSK3 inhibitor
M20198 WAY-606957 WAY-606957 is a inhibitor of GSK3 kinases.
M20197 WAY-606956 WAY-606956 is a inhibitor of GSK3 kinases.
M20196 WAY-606954 WAY-606954 is a inhibitor of GSK3 kinases.
M20192 WAY-603610 WAY-603610 is a inhibitor of GSK3 kinases.
M20175 WAY-381785 WAY-381785 is a inhibitor of GSK3 kinases.
M20171 WAY-358024 WAY-358024 is a GSK-3b inhibitor
M20148 WAY-344977 WAY-344977 is a inhibitor of Glycogen Synthase Kinase 3.
M20114 WAY-326578 WAY-326578 has GSK-3b inhibition.
M20098 WAY-322545 WAY-322545 altering the lifespan of a eukaryotic organism
M20045 WAY-271413 WAY-271413 is a GSK-3β inhibitor.
M14839 KY19382 KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β, with IC50s of 19 and 10 nM, respectively.
M14838 GSK-3 inhibitor 1 GSK-3 inhibitor 1 is an inhibitor of GSK-3.



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