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9-ing-41

Cat. No. M20731
9-ing-41 Structure
Size Price Availability Quantity
5mg USD 130  USD130 In stock
10mg USD 210  USD210 In stock
25mg USD 450  USD450 In stock
50mg USD 770  USD770 In stock
100mg USD 1350  USD1350 In stock
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Biological Activity

9-ING-41 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with antitumor activity. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.

Chemical Information
Molecular Weight 404.35
Formula C22H13FN2O5
CAS Number 1034895-42-5
Solubility (25°C) DMSO 81 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Andrew Hsu, et al. Cancer Biol Ther. Clinical activity of 9-ING-41, a small molecule selective glycogen synthase kinase-3 beta (GSK-3β) inhibitor, in refractory adult T-Cell leukemia/lymphoma

[2] Andrey Poloznikov, et al. Front Pharmacol. 9-ING-41, a Small Molecule Inhibitor of GSK-3β, Potentiates the Effects of Chemotherapy on Colorectal Cancer Cells

[3] Robin Park, et al. Biology (Basel). GSK-3β in Pancreatic Cancer: Spotlight on 9-ING-41, Its Therapeutic Potential and Immune Modulatory Properties

[4] Hiroo Kuroki, et al. Sci Rep. 9-ING-41, a small molecule inhibitor of GSK-3beta, potentiates the effects of anticancer therapeutics in bladder cancer

[5] Andrey V Ugolkov, et al. Anticancer Drugs. 9-ING-41, a small-molecule glycogen synthase kinase-3 inhibitor, is active in neuroblastoma

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Keywords: 9-ing-41 supplier, GSK-3, inhibitors, activators
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