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 About 30 results found for searched term "GSK-3" (0.009 seconds)

Cat.No.  Name Target
M1719 GSK461364 PLK
GSK461364 is a potent and selective small molecule inhibitor of Polo-like kinase 1 (PLK1) with a Ki of 2.2 nM.
M1758 Foretinib c-Met
XL880, GSK1363089
Foretinib (XL880, GSK1363089) is a multi-targeted inhibitor of c-Met and vascular endothelial growth factor receptor 2 (VEGFR2) with IC50 value of 0.4 nM for c-MET.
M1789 GSK690693 Akt
GSK690693 is a potent Akt inhibitor (Akt1 IC50 = 2 nM, Akt2 IC50 = 13 nM, Akt3 IC50 = 9 nM) which also inhibited the phosphorylation of the downstream target GSK3b in cells.
M1855 Dabrafenib Mesylate Raf
Dabrafenib (GSK2118436) is a selective, orally bioavailable inhibitor of Mutant B-raf (BRAF) protein kinase with potential antineoplastic activity.
M1932 GSK1838705A ALK
GSK1838705A is a small-molecule kinase inhibitor that inhibits IGF-IR and the insulin receptor with IC50s of 2.0 and 1.6 nmol/L, respectively.
M1988 Dabrafenib Raf
Dabrafenib (free base) (GSK2118436A) is a V600 mutant BRAF-specific inhibitor.
M2033 GSK 3787 PPAR
GSK3787 is an orally available selective peroxisome proliferator-activated receptor δ (PPARδ) antagonist (pIC50 = 6.6).
M2050 GSK2636771 PI3K
GSK2636771 is a potent, orally available and specific PI3K p110β (PI3K beta, PI3Kβ) inhibitor.
M2115 GSK2334470 PDK1
GSK2334470 is a highly specific and potent inhibitor of PDK1 with IC50 of 10 nM.
M2171 GSK923295 Kinesin
GSK923295 is an allosteric inhibitor of CENP-E with Ki value of 3.2 nM.
M2405 AR-A014418 GSK-3
GSK-3β Inhibitor VIII
AR-A014418 is an ATP-competitive, and selective GSK3β inhibitor with IC50 and Ki of 104 nM and 38 nM, without significant inhibition on 26 other kinases tested.
M2736 GSK343 EZH2
GSK343 is a potent and selective EZH2 inhibitor with IC50 of 4 nM, showing 60 fold selectivity against EZH1, and >1000 fold selectivity against other histone methyltransferases.
M3054 TDZD-8 GSK-3
GSK-3β Inhibitor I; NP 01139
TDZD-8 is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.
M3321 GSK1292263 GPR/FFAR
GSK1292263 is a novel GPR119 agonist, showing potential for the treatment of type 2 diabetes.
M3484 Dolutegravir Integrase
Dolutegravir (GSK1349572) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM, modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.
M3715 GSK2838232A HIV Protease
GSK2838232 is a novel human immune virus (HIV) maturation inhibitor being developed for the treatment of chronic HIV infection.
M3751 Losmapimod p38 MAPK
GW-856553X; GSK-AHAB; SB856553
Losmapimod (GW856553) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively.
M4804 GSK-503 Histone Methyltransferase
GSK-503 is a potent EZH2 inhibitor with potential anticancer activity.
M4824 Dolutegravir sodium Integrase
GSK-1349572A, DTG
Dolutegravir sodium is a potent, second generation HIV integrase inhibitor (IC₅₀ = 2.7 nM) that displays potent antiviral activity.
M4954 EPZ015666 PRMTs
EPZ015666 is a potent, selective and orally bioavailable PRMT5 inhibitor with Ki of 5 nM, >20,000-fold selectivity over other PMTs.
M5187 GSK137647A GPR/FFAR
GSK 137647
GSK137647A is a selective FFAR4 (GRP120) agonist for human, Mouse and Rat FFA4 with pEC50 values of 6.3, 6.2 and 6.1, respectively. GSK137647A induces insulin secretion and inhibits epithelial ion transport.
M5210 GSK1325756 (Danirixin) CXCR
GSK1325756 (Danirixin) is a non-peptide, high affinity, selective and reversible CXCR2 antagonist, with IC50 of 12.5 nM for CXCL8.
M5232 GSK583 RIPK
GSK583 is a highly potent and selective inhibitor of RIP2 kinase with an IC50 of 5 nM.
M5269 GSK180736A ROCK
GSK180736A, developed as a Rho-associated, coiled-coil-containing protein kinase inhibitor, binds to GRK2(G protein-coupled receptor kinase 2) with logIC50 pf -6.6 (logIC50 -4.0 for GRK5 and >-3 for GRK1); ≥400-fold selective for GRK2 over both GRK1 and GRK5.
M5271 GSK6853 Epigenetic Reader Domain
GSK6853 is a selective benzimidazolone BRPF1 inhibitor with pIC50 of 8.1(TR-FRET) showing greater than 1600-fold selectivity over all other bromodomains tested.
M5308 Afuresertib Akt
GSK2110183; LAE002
Afuresertib (GSK2110183; LAE002) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively.
M5325 GSK 650394 SGK
GSK650394 is a serum- and glucocorticoid-regulated kinase-1 inhibitor with IC50 of 62 nM and 103 nM for SGK1 and SGK2, respectively.
M6161 GSK369796 Dihydrochloride Potassium Channel
GSK369796 shows antimalerial activity with IC50 values of 11.2 nM for 3D7 strain, 12.6 nM for HB3 strain, 17.6 nM for K1 strain.
M6768 GSK2033 Liver X Receptor
GSK 2033
GSK2033 is a potent LXR antagonist.
M6770 GSK 2830371 Phosphatase
GSK 2830371 is a potent and selective allosteric inhibitor of Wip1 phosphatase.

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