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GSK2033

Cat. No. M6768
GSK2033 Structure
Synonym:

GSK 2033

Size Price Availability Quantity
5mg USD 110  USD110 In stock
10mg USD 190  USD190 In stock
25mg USD 415  USD415 In stock
50mg USD 720  USD720 In stock
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Quality Control
Biological Activity

GSK2033 is a potent LXR antagonist with pIC50s of 7 and 7.4 for LXRα or LXRβ, respectively. GSK2033 enhances T-cell proliferation and blocks T 0901317-antiproliferative activity on T-cells. GSK2033 is cell permeable.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 591.66
Formula C29H28F3NO5S
CAS Number 1221277-90-2
Purity >99%
Solubility DMSO 22 mg/mL (Need warming)
Storage at -20°C
References

[1] Kristine Griffett, et al. Biochem Biophys Res Commun. Promiscuous activity of the LXR antagonist GSK2033 in a mouse model of fatty liver disease

[2] Consoli, et al. Eur.J Pharmacol. Behavioral effects of the β3 adrenoceptor agonist SR58611A: is it the putative prototype of a new class of antidepressant/anxiolytic drugs?.

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Keywords: GSK2033, GSK 2033 supplier, Liver X Receptor, inhibitors

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