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LXR-623

Cat. No. M6087

All AbMole products are for research use only, cannot be used for human consumption.

LXR-623 Structure
Synonym:

WAY-252623

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 60  USD60 In stock
5mg USD 60  USD60 In stock
10mg USD 82  USD82 In stock
50mg USD 324  USD324 In stock
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Quality Control & Documentation
Biological Activity

LXR-623 suppresses LDLR expression, increases expression of the ABCA1 efflux transporter, and induces substantial cell death in all of the GBM samples tested. The brain metastatic breast cancer cell line MDA-MB-361, which harbors ERBB2 amplification, is also highly sensitive to LXR-623- dependent cell death in a concentration-dependent manner. LXR-623 inhibits LDL uptake and induces cholesterol efflux in GBM cells, resulting in a significant reduction in cellular cholesterol content. Normal brain cell insensitivity to LXR-623 may be due to reliance on endogenous synthesis of cholesterol and intact negative feedback through synthesis of endogenous oxysterols

Protocol (for reference only)
Cell Experiment
Cell lines Human PBMC
Preparation method The purified PBMC are resuspended in culture medium (RPMI + 10% fetal calf serum + 1% penicillin/streptomycin with 1% L-glutamine), transferred to 6-well (9.5 cm2 each) tissue culture dishes at approximately 5 × 106 cells per well, and 2 μM LXR-623 or vehicle (DMSO) are added. After 18 hours of culture, RNA isolation and qPCR analysis for LXRα, LXRβ, ABCA1, ABCG1, and PLTP is performed.
Concentrations 2 μM
Incubation time 18 h
Animal Experiment
Animal models C57/Bl6 mice
Formulation 0.1% DMSO
Dosages 30 mg/kg
Administration oral
Chemical Information
Molecular Weight 422.78
Formula C21H12ClF5N2
CAS Number 875787-07-8
Solubility (25°C) DMSO 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Villa GR, et al. Cancer Cell. An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers.

[2] Katz A, et al. J Clin Pharmacol. Safety, pharmacokinetics, and pharmacodynamics of single doses of LXR-623, a novel liver X-receptor agonist, in healthy participants.

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Keywords: LXR-623, WAY-252623 supplier, Liver X Receptor, inhibitors, activators

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