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Cat. No. M2204
T0901317 Structure
Size Price Availability Quantity
10mg USD 57  USD57 In stock
50mg USD 115  USD115 In stock
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Quality Control & Documentation
Biological Activity

T0901317 is a potent, high affinity liver X receptor (LXR) agonist. T0901317 binds and activates PXR with the same nanomolar potency with which it stimulates LXR activity. T0901317 induces expression not only of LXR target genes, but also of PXR target genes in cells and animals. T0901317 decreases amyloid-β production in primary neurons in vitro. T0901317 also exhibits inverse agonist activity at constitutive androstane receptors (CAR). Although T0901317 is a much more potent activator of LXR than FXR, this ligand actually activates FXR more potently than a natural bile acid FXR ligand, chenodeoxycholic acid. T0901317 treatment of 11-week-old APP23 mice for 6 days showed a significant increase in ABCA1 expression and a decrease in the ratio of soluble APP (sAPP)beta- to sAPPalpha-cleavage products. T0901317 decreases amyloidogenic processing of APP in vitro and in vivo, thus supporting the search for potent and specific LXR ligands with properties allowing therapeutic application.

Customer Product Validations & Biological Datas
Source ARYA Atheroscler (2017). Figure 1. T0901317
Method PCR
Cell Lines Mice
Concentrations 30 mg/kg
Incubation Time 48 hour
Results In fact, a combination of T0901317 and anti-miR-33 insignificantly increased ABCA1 gene expression
Chemical Information
Molecular Weight 481.33
Formula C17H12F9NO3S
CAS Number 293754-55-9
Solubility (25°C) DMSO 72 mg/mL
Ethanol 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Kumar N, et al. Mol Pharmacol. The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist.

[2] Koldamova RP, et al. J Biol Chem. The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease.

[3] Houck KA, et al. Mol Genet Metab. T0901317 is a dual LXR/FXR agonist.

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Keywords: T0901317 supplier, Liver X Receptor, inhibitors, activators

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