Free shipping on all orders over $ 500

T0901317

Cat. No. M2204

All AbMole products are for research use only, cannot be used for human consumption.

T0901317 Structure
Size Price Availability Quantity
10mg USD 57  USD57 In stock
50mg USD 115  USD115 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

T0901317 is a potent, high affinity liver X receptor (LXR) agonist. T0901317 binds and activates PXR with the same nanomolar potency with which it stimulates LXR activity. T0901317 induces expression not only of LXR target genes, but also of PXR target genes in cells and animals. T0901317 decreases amyloid-β production in primary neurons in vitro. T0901317 also exhibits inverse agonist activity at constitutive androstane receptors (CAR). Although T0901317 is a much more potent activator of LXR than FXR, this ligand actually activates FXR more potently than a natural bile acid FXR ligand, chenodeoxycholic acid. T0901317 treatment of 11-week-old APP23 mice for 6 days showed a significant increase in ABCA1 expression and a decrease in the ratio of soluble APP (sAPP)beta- to sAPPalpha-cleavage products. T0901317 decreases amyloidogenic processing of APP in vitro and in vivo, thus supporting the search for potent and specific LXR ligands with properties allowing therapeutic application.

Customer Product Validations & Biological Datas
Source ARYA Atheroscler (2017). Figure 1. T0901317
Method PCR
Cell Lines Mice
Concentrations 30 mg/kg
Incubation Time 48 hour
Results In fact, a combination of T0901317 and anti-miR-33 insignificantly increased ABCA1 gene expression
Chemical Information
Molecular Weight 481.33
Formula C17H12F9NO3S
CAS Number 293754-55-9
Solubility (25°C) DMSO 72 mg/mL
Ethanol 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kumar N, et al. Mol Pharmacol. The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist.

[2] Koldamova RP, et al. J Biol Chem. The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease.

[3] Houck KA, et al. Mol Genet Metab. T0901317 is a dual LXR/FXR agonist.

Related Liver X Receptor Products
Rovazolac

Rovazolac is a liver x receptor (LXR) modulator, which can be used in the study of immune system disorders and atopic dermatitis.

GW6340

GW6340 is an intestinal-specific LXR agonist.

Larsucosterol

Larsucosterol is an endogenous sulfated oxysterol and a potent hepatic X receptor (LXR) and DNA methylase (DNMTS) antagonist that regulates endogenous lipogenesis as well as inhibits cholesterol biosynthesis by lowering mRNA levels and inhibiting SREBP-1 activation. May be used in studies related to psoriasis.

24(S)-Hydroxycholesterol

24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators.

GW3965 

GW3965 is a potent, selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively.

  Catalog
Abmole Inhibitor Catalog




Keywords: T0901317 supplier, Liver X Receptor, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.