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24(S)-Hydroxycholesterol

Cat. No. M30137
24(S)-Hydroxycholesterol Structure
Synonym:

24S-OHC; 24S-HC; Cerebrosterol

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Biological Activity

24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators.

Chemical Information
Molecular Weight 400.68
Formula C28H48O
CAS Number 474-73-7
Form Solid
Storage Powder -20°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Paola Gamba, et al. Antioxidants (Basel). The Controversial Role of 24-S-Hydroxycholesterol in Alzheimer's Disease

[2] Yasuomi Urano, et al. Cell Death Discov. 24( S)-Hydroxycholesterol induces ER dysfunction-mediated unconventional cell death

[3] Noriko Noguchi, et al. Free Radic Biol Med. New aspects of 24(S)-hydroxycholesterol in modulating neuronal cell death

[4] Min-Yu Sun, et al. Neuroscientist. 24(S)-Hydroxycholesterol as a Modulator of Neuronal Signaling and Survival

[5] Noriko Noguchi, et al. Biochem Biophys Res Commun. Diverse functions of 24(S)-hydroxycholesterol in the brain

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Keywords: 24(S)-Hydroxycholesterol, 24S-OHC; 24S-HC; Cerebrosterol supplier, Liver X Receptor, inhibitors, activators


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