Free shipping on all orders over $ 500


Cat. No. M4874
SR9243 Structure
Size Price Availability Quantity
10mM*1mL in DMSO USD 88  USD88 In stock
5mg USD 65  USD65 In stock
10mg USD 90  USD90 In stock
25mg USD 150  USD150 In stock
50mg USD 270  USD270 In stock
100mg USD 480  USD480 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

In HEK293 cells expressing LXRs, SR9243 inhibits LXR activation by enhancing LXR-corepressor recruitment. In a variety of cancer cell types, SR9243 reduces cancer cell viability, induces apoptotic cell death, and sensitizes cancer cells to chemotherapeutic treatments.

Customer Product Validations & Biological Datas
Source Biomed Res Int (2018). Figure 1. SR9243
Method q.d. i.p.
Cell Lines mice
Concentrations 30mg/kg
Incubation Time 30 days
Results Based on this diet,we induced chemical damage-induced NASH and biliary NASH, and on the NASH model we examined the potential efficacy of SR9243. As shown by Masson trichrome staining of liver tissue (Figure 1), we clearly observed from the pathological point of view, BDL significantly exacerbated liver fibrosis in both the control diet and HC diet group.
Chemical Information
Molecular Weight 626.62
Formula C31H32BrNO4S2
CAS Number 1613028-81-1
Solubility (25°C) DMSO ≥ 6 mg/mL (Need ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Flaveny CA, Cancer Cell. Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis.

Related Liver X Receptor Products

Rovazolac is a liver x receptor (LXR) modulator, which can be used in the study of immune system disorders and atopic dermatitis.


GW6340 is an intestinal-specific LXR agonist.


Larsucosterol is an endogenous sulfated oxysterol and a potent hepatic X receptor (LXR) and DNA methylase (DNMTS) antagonist that regulates endogenous lipogenesis as well as inhibits cholesterol biosynthesis by lowering mRNA levels and inhibiting SREBP-1 activation. May be used in studies related to psoriasis.


24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators.


GW3965 is a potent, selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively.

Abmole Inhibitor Catalog

Keywords: SR9243 supplier, Liver X Receptor, inhibitors, activators

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.