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GSK1325756

Cat. No. M5210
GSK1325756 Structure
Synonym:

Danirixin

Size Price Availability Quantity
10mM/1mL USD 360  USD400 In stock
2mg USD 216  USD240 In stock
5mg USD 337.5  USD375 In stock
10mg USD 486  USD540 In stock
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Quality Control
Biological Activity

GSK1325756 (Danirixin) is a non-peptide, high affinity, selective and reversible CXCR2 antagonist (IC50 for CXCL8 = 12.5 nM). GSK1325756 has demonstrated potent antagonism of CXCR2 activity in vitro and anti-inflammatory effects in various preclinical models. Danirixin (GSK1325756) is used for the treatment of chronic obstructive pulmonary disease (COPD).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 441.9
Formula C19H21ClFN3O4S
CAS Number 954126-98-8
Purity >99%
Solubility DMSO
Storage at -20°C
References

Assessment of potential d rug interactions by characterization of human dr ug metabolism pathways using non-invasive bile sampling.
Bloomer JC, et al. Br J Clin Pharmacol. 2013 Feb;75(2):488-96. PMID: 22670830.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: GSK1325756, Danirixin supplier, CXCR, inhibitors

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