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Indirubin

Cat. No. M2184
Indirubin Structure
Synonym:

C.I.73200; Couroupitine B; Indigo red; Indigopurpurin

Size Price Availability Quantity
5mg USD 69  USD69 In stock
10mg USD 97  USD97 In stock
25mg USD 160  USD160 In stock
50mg USD 330  USD330 In stock
100mg USD 480  USD480 In stock
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Quality Control & Documentation
Biological Activity

Indirubin is a cyclin-dependent kinase inhibitor which functions by competing with ATP for binding to the catalytic subunit. Indirubin is used in traditional Chinese medicine for anti-inflammatory, anti-tumor, and neuroprotective effects. Indirubin inhibits glycogen synthase kinase-3 (IC50 = 2.5 μM) and cyclin-dependent kinases 1 and 5 (IC50 = 10 μM for both isoforms). Indirubin also inhibits CDK1/5 with IC50 of 10 μM and 5.5 μM. Indirubin exhibits antiproliferative activity leading to G2/M arrest in many cell lines and G1/S arrest in Jurkat cells. Indirubin induces cell cycle arrest and inhibits cell proliferation.

Chemical Information
Molecular Weight 262.26
Formula C16H10N2O2
CAS Number 479-41-4
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Leclerc S, et al. J Biol Chem. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?

[2] Hoessel R, et al. Nat Cell Biol. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases.

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Keywords: Indirubin, C.I.73200; Couroupitine B; Indigo red; Indigopurpurin supplier, GSK-3, inhibitors, activators

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