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Indirubin is a cyclin-dependent kinase inhibitor which functions by competing with ATP for binding to the catalytic subunit. Indirubin is used in traditional Chinese medicine for anti-inflammatory, anti-tumor, and neuroprotective effects. Indirubin inhibits glycogen synthase kinase-3 (IC50 = 2.5 μM) and cyclin-dependent kinases 1 and 5 (IC50 = 10 μM for both isoforms). Indirubin also inhibits CDK1/5 with IC50 of 10 μM and 5.5 μM. Indirubin exhibits antiproliferative activity leading to G2/M arrest in many cell lines and G1/S arrest in Jurkat cells. Indirubin induces cell cycle arrest and inhibits cell proliferation.
Molecular Weight | 262.26 |
Formula | C16H10N2O2 |
CAS Number | 479-41-4 |
Solubility (25°C) | DMSO 50 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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