| Cat.No. | Name | Information |
|---|---|---|
| M1692 | CHIR-99021 | CHIR-99021 (CT99021) is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively. |
| M2304 | TWS119 | TWS119 is a GSK-3β inhibitor with IC50 of 30 nM. |
| M1989 | CHIR-99021 HCl | CHIR-99021 HCl (Laduviglusib; CT99021) is a hydrochloride of CHIR-99021, with IC50 of 10 nM and 6.7 nM for GSK-3α and GSK-3β, respectively. |
| M7627 | BIO | BIO (GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052) is a specific GSK-3 inhibitor, the IC50 acting on GSK-3α/β in cell-free assays is 5 nM, which is more than 16 times more selective than ACTing on CDK5. It is also a pan-JAK inhibitor with an IC50 value of 30 nM for Tyk2. BIO induces apoptosis in human melanoma cells. |
| M49763 | PF-04802367 | PF-04802367 (PF-367) is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay. PF-04802367 shows desirable central nervous system (CNS) properties and potency. |
| M49762 | L803-mts | L803-mts (Myristoylated L 803) is a selective and substrate-competitive GSK-3 peptide inhibitor (IC50: 40 μM). |
| M49761 | GSK-3β inhibitor 8 | GSK-3β inhibitor 8, a thiophenacil derivative, is an effective and selective inhibitor of GSK-3β (IC50=64 nM). |
| M49760 | GSK-3β inhibitor 7 | GSK-3β inhibitor 7 is a GSK-3β inhibitor with an IC50 value of 5.25 μM. |
| M49759 | GSK-3β inhibitor 6 | GSK-3β inhibitor 6 is a potent GSK-3β inhibitor with an IC50 value of 24.4 μM. |
| M49758 | GSK-3β inhibitor 3 | GSK-3β inhibitor 3 is a potent, selective, irreversible and covalent inhibitor of Glycogen Synthase Kinase 3β (GSK-3β), with an IC50 of 6.6 μM. |
| M49756 | GSK3-IN-1 | GSK3-IN-1 is a GSK-3 inhibitor with an IC50 value of 12 μM. |
| M49755 | Cu(II)GTSM | Cu(II)GTSM, a cell-permeable Cu-complex, significantly inhibits GSK3β. |
| M49754 | C-Peptide 1 (rat) | C-Peptide 1 (rat), a peptide, is aβ-catenin/GSK-3β activator. |
| M49753 | Cazpaullone | Cazpaullone is a glycogen synthase kinase-3 (GSK-3) inhibitor. |
| M49752 | BRD5648 | BRD5648 ((R)-BRD0705) is a negative control of BRD0705. |
| M49751 | ARN25068 | ARN25068 is a sub-micromolar inhibitor of the three protein kinases, GSK-3β, FYN and DYRK1A to tackle tau hyperphosphorylation. |
| M49750 | 5-Iodo-indirubin-3'-monoxime | 5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively. |
| M49749 | 2B-(SP) (TFA) | 2B-(SP) TFA is a eIF2B-based substrate for glycogen synthase kinase-3 (GSK-3). |
| M49748 | 2B-(SP) | 2B-(SP) is a eIF2B-based substrate for glycogen synthase kinase-3 (GSK-3). |
| M49747 | Lithium chloride hydrate | Lithium chloride hydrate, an orally active mood stabilizer, is a potent virus inhibitor and effective immunomodulatory agent. |
| M49746 | GSK3β inhibitor II | GSK3β inhibitor II is an inhibitor of GSK3β. |
| M49745 | GSK-3 Inhibitor XIII | GSK-3 Inhibitor XIII is a potent and ATP-competitive GSK-3 inhibitor with a Ki of 24 nM. |
| M49736 | hAChE-IN-5 | hAChE-IN-5 is a potent hAChE and hBuChE inhibitor with IC50 values of 0.17 μM and 0.17 μM, respectively. |
| M43382 | 6-Me-ATP | 6-Me-ATP (N6-Methyl-ATP) is a N6-modified ATP derivative. |
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