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Cat. No. M21232
MeBIO Structure


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5mg USD 90  USD90 4-7 Days
10mg USD 150  USD150 4-7 Days
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Quality Control & Documentation
Biological Activity

MeBIO, an analog of 6-bromoindirubin-3'-oxime, has been suggested to possess the structural basis for a potent and selective inhibitor of glycogen synthase kinase-3 (GSK3) and cyclin-dependent kinases. MeBIO displays minimal activity against CDK1/Cyclin B, GSK-3, and CDK5/p25 (IC50 values are 92.0, 44-100 and >100 μM respectively). MeBIO is inactive on GSK-3β. MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist.

Chemical Information
Molecular Weight 370.20
Formula C17H12BrN3O2
CAS Number 667463-95-8
Solubility (25°C) DMSO 10 mg/mL (May need warming and ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Felix Wei, et al. Stroke. Arterial Tortuosity: An Imaging Biomarker of Childhood Stroke Pathogenesis?

[2] Takahisa Kato, et al. Int J Comput Assist Radiol Surg. Tendon-driven continuum robot for neuroendoscopy: validation of extended kinematic mapping for hysteresis operation

[3] Laurent Meijer, et al. Chem Biol . GSK-3-selective inhibitors derived from Tyrian purple indirubins

[4] Kazuma Kishi, et al. Kansenshogaku Zasshi. [A clinical study of cryptococcal meningitis--sequential changes of cryptococcal antigen titers]

[5] A Torreggiani, et al. Biospectroscopy. The binding of biotin analogues by streptavidin: a Raman spectroscopic study

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Abmole Inhibitor Catalog

Keywords: MeBIO, 6-bromoindirubin-3'-oxime supplier, GSK-3, inhibitors, activators

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