| Description: |
MeBIO, an analog of 6-bromoindirubin-3'-oxime, has been suggested to possess the structural basis for a potent and selective inhibitor of glycogen synthase kinase-3 (GSK3) and cyclin-dependent kinases. MeBIO displays minimal activity against CDK1/Cyclin B, GSK-3, and CDK5/p25 (IC50 values are 92.0, 44-100 and >100 μM respectively). MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist. |
| Stability and Solubility Advice: |
Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |
