Free shipping on all orders over $ 500


Cat. No. M8228
Bikinin Structure


Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 90  USD90 In stock
50mg USD 210  USD210 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Bikinin is a strong activator of brassinosteroid (BR) signaling. It is an Arabidopsis GSK-3 Inhibitor, an Arabidopsis SHAGGY-related Kinase Inhibitor, and a GSK-3-like Kinase BIN2 Inhibitor. Bikinin directly inhibits BIN2 (group II GSK3s) by interfering with ATP binding. Bikinin is specific toward a subset of Arabidopsis GSK3 kinases including BIN2 and ASK α, γ, ε, ι, and θ.

Chemical Information
Molecular Weight 273.08
Formula C9H9BrN2O3
CAS Number 188011-69-0
Solubility (25°C) DMSO ≥ 25 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Wilfried Rozhon, et al. Inhibitors of Brassinosteroid Biosynthesis and Signal Transduction

[2] Takema Sasaki, et al. Imaging of Developing Metaxylem Vessel Elements in Cultured Hypocotyls

[3] Hye Jo Min, et al. OsBZR1 turnover mediated by OsSK22-regulated U-box E3 ligase OsPUB24 in rice BR response

[4] Kyoko Yamazaki, et al. Suppression of DELLA signaling induces procambial cell formation in culture

[5] Wilfried Rozhon, et al. Bikinin-like inhibitors targeting GSK3/Shaggy-like kinases: characterisation of novel compounds and elucidation of their catabolism in planta

Related GSK-3 Products

6-Me-ATP (N6-Methyl-ATP) is a N6-modified ATP derivative.

PROTAC GSK-3β Degrader-1

PROTAC GSK-3β Degrader-1 is a degrader targets GSK-3β degradation with an IC50 value of 833 nM.

GSK-3β inhibitor 13

GSK-3β inhibitor 13 is an orally active and potent GSK-3β inhibitor with blood-brain permeability.

GSK-3 inhibitor 3

GSK-3 inhibitor 3 is a selective, orally active and brain-penetrant inhibitor of GSK-3, with IC50s of 0.35 nM and 0.25 nM for GSK-3α and GSK-3β, respectively.

GSK-3 inhibitor 4

GSK-3 inhibitor 4 is an orally active and brain-penetrant inhibitor of GSK-3, CDK2, and CDK5, with IC50 values of 0.56 nM (GSK-3β), 0.45 nM (GSK-3α), 0.47 μM, and 0.68 μM, respectively.

Abmole Inhibitor Catalog

Keywords: Bikinin, Abrasin supplier, GSK-3, inhibitors, activators

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.