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Simufilam (PTI-125) Dihydrochloride is a small molecule modulator that preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.
| Molecular Weight | 332.27 |
| Formula | C15H23Cl2N3O |
| CAS Number | 2480226-06-8 |
| Solubility (25°C) | DMSO 66 mg/mL Water 66 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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