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BIIE-0246 hydrochloride (AR-H 053591 hydrochloride) is a potent and selective NPY2R (neuropeptide Y receptor 2) antagonist with an IC50 value of 15 nM for rat [125I]PYY3-36. BIIE-0246 hydrochloride decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated. BIIE-0246 hydrochloride reduces albuminuria in ADR nephropathy.
| Formula | C49H57N11O6.xHCl |
| CAS Number | 246146-55-4 (free base) |
| Form | Solid |
| Solubility (25°C) | DMSO 30 mg/mL (Need ultrasonic and warming) |
| Storage | 4°C, dry, sealed |
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