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TAK-659 hydrochloride is a highly selective, reversible, orally potent dual inhibitor of SYK/FLT3 that acts on SYK and FLT3 IC50 The values are 3.2 nM and 4.6 nM, respectively. TAK-659 hydrochloride induces tumor cell death without acting on non-tumor cells, with potential to study chronic lymphocytic leukemia (CLL).
| Molecular Weight | 380.85 |
| Formula | C17H22ClFN6O |
| CAS Number | 1952251-28-3 |
| Solubility (25°C) | DMSO < 1 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Syk Products |
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| GSK143
GSK143 is an orally active and highly selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.5. |
| PRT062607
PRT062607(P505-15; PRT-2607; BIIB-057) is a highly specific and potent inhibitor of Syk with IC50 of 1-2 nM; >80-fold selective for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70. |
| GSK143 dihydrochloride
GSK143 dihydrochloride is an orally active and highly selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.5. |
| Syk Kinase Peptide Substrate
Syk Kinase Peptide Substrate is a Syk kinase peptide substrate. |
| TOP1288
TOP1288 is an SRC/Syk/p38α inhibitor for studies related to ulcerative colitis. |
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