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About 25 results found for searched term "Syk" (0.038 seconds)
| Cat.No. | Name | Information |
|---|---|---|
| M1767 | R-406 | R406 is an orally bioavailable and selective inhibitor of spleen tyrosine kinase (Syk) with the IC50 of 41nM and Ki value of 30 nM. |
| M1847 | Fostamatinib disodium | Fostamatinib disodium (R788, R-935788) is a potent, ATP-competitive and selective Syk (Spleen tyrosine kinase) inhibitor with IC50 of 41 nM. |
| M1990 | Fostamatinib (R788) | Fostamatinib (R788) is a spleen tyrosine kinase (Syk) inhibitor with IC50 of 41 nM. |
| M2063 | P505-15 hydrochloride | P505-15 (PRT062607) is a novel, highly selective inhibitor of Syk with IC50 value of 1-2 nM. |
| M2729 | GS-9973 | GS-9973 is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM. |
| M2850 | Midostaurin | Midostaurin (pkc412) is a multi-targeted kinase inhibitor, including PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50 ranging from 80-500 nM. |
| M2862 | MNS | MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively. |
| M2941 | Piceatannol | Piceatannol, a natural stilbene, is a selective Syk inhibitor and ~10-fold selectivity versus Lyn. |
| M4870 | Cerdulatinib | Cerdulatinib (PRT-062070, PRT2070) is an orally active multi-target tyrosine kinase inhibitor with IC50s of JAK1/JAK2/JAK3/TYK2 and Syk 12 nM/6 nM/8 nM/0.5 nM and 32 nM, respectively. It was also able to inhibit the other 19 kinases tested, all with IC50 below 200 nM. |
| M5028 | JANEX-1 | Janex-1 is a cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (IC50 = 78 μM); has no effect on JAK1, JAK2, or Zap/Syk or SRC tyrosine kinases. |
| M5247 | BAY 61-3606 dihydrochloride | BAY-61-3606 is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM). |
| M5252 | PRT-060318 | PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase, with IC50 of 4 nM. |
| M6715 | ER 27319 maleate | ER 27319 maleate is a selective Syk kinase inhibitor. |
| M7093 | OXSI 2 | OXSI 2 is a potent Syk kinase inhibitor; also inhibits assembly of NLRP3 inflammasomes. |
| M9012 | R112 | R112 is an ATP-competitive inhibitor of Syk kinase with an IC50 of 226 nM. |
| M10688 | TAK-659 | TAK-659 hydrochloride is a highly selective, reversible, orally potent dual inhibitor of SYK/FLT3 that acts on SYK and FLT3 IC50 The values are 3.2 nM and 4.6 nM, respectively. TAK-659 hydrochloride induces tumor cell death without acting on non-tumor cells, with potential to study chronic lymphocytic leukemia (CLL). |
| M10740 | Gusacitinib | Gusacitinib (ASN-002) is a potent dual inhibitor of SYK kinase and JAK kinase,IC50 Values are 5-46 nM. Gusacitinib has anti-cancer activity in both solid and hematological tumors. |
| M14915 | Cerdulatinib hydrochloride | Cerdulatinib hydrochloride (PRT062070) is a selective, oral active and reversible ATP-competitive inhibitor of dual SYK and JAK, with IC50s of 32 nM, 0.5 nM, 12 nM, 6 nM and 8 nM for SYK and Tyk2, JAK1, 2, 3, respectively. |
| M14916 | R406 besylate | R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. |
| M20069 | WAY-299721 | WAY-299721 is a impede the interaction of Syk with its cellular partners while maintaining an active kinase protein (Syk inhibitor) |
| M20371 | WAY-321341 | WAY-321341 is a syk inhibitor |
| M20593 | RO9021 | RO9021 potently inhibits SYK kinase activity with an average IC50 of 5.6 nM and suppresses B-cell receptor signaling. |
| M20797 | SRX3207 | SRX3207 is an orally active dual inhibitor of Syk-PI3K with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively. SRX3207 blocks tumor immunosuppression and increases anti-tumor immunity. |
| M20799 | GS-9876 (lanraplenib) | Lanraplenib (GS-9876, GS-SYK) is a potent, highly selective and orally active inhibitor of Spleen Tyrosine Kinase (SYK) with IC50 of 9.5 nM. Lanraplenib inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. |
| M21588 | GSK2646264 | GSK2646264 is a potent and selective splenic tyrosine kinase (Syk) inhibitor with a pIC50 value of 7.1. GSK2646264 also inhibited other kinases, with pIC50 values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3 for LCK, LRRK2, GSK3β, JAK2, VEGFR2, Aurora B and Aurora A, respectively. GSK2646264 penetrates into the epidermis and dermis of the skin. |
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