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GS-9876 (lanraplenib)

Cat. No. M20799

All AbMole products are for research use only, cannot be used for human consumption.

GS-9876 (lanraplenib) Structure
Synonym:

GS-SYK

Size Price Availability Quantity
5mg USD 138  USD138 In stock
10mg USD 230  USD230 In stock
50mg USD 610  USD610 In stock
100mg USD 1000  USD1000 In stock
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Quality Control & Documentation
Biological Activity

Lanraplenib (GS-9876, GS-SYK) is a potent, highly selective and orally active inhibitor of Spleen Tyrosine Kinase (SYK) with IC50 of 9.5 nM. Lanraplenib inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans.

Chemical Information
Molecular Weight 443.5
Formula C23H25N9O
CAS Number 1800046-95-0
Solubility (25°C) DMSO 89 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Su'an Tang, et al. Expert Opin Investig Drugs. Investigational spleen tyrosine kinase (SYK) inhibitors for the treatment of autoimmune diseases

[2] Peter Blomgren, et al. ACS Med Chem Lett. Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases

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  Catalog
Abmole Inhibitor Catalog




Keywords: GS-9876 (lanraplenib), GS-SYK supplier, Syk, inhibitors, activators

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