Certificate of Analysis

 

Product Name: GS-9876 (lanraplenib)
Catalog Number: M20799
CAS Number: 1800046-95-0

Physical and Chemical Properties
Formula: C23H25N9O
Molecular Weight: 443.5
Solubility: DMSO 89 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: GS-9876 (lanraplenib) Structure
Analytical Data
QC Standard: >99%
H-NMR: Consistent with structure
Product Information
Description: Lanraplenib (GS-9876, GS-SYK) is a potent, highly selective and orally active inhibitor of Spleen Tyrosine Kinase (SYK) with IC50 of 9.5 nM. Lanraplenib inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.