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GS-9973 is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM, which is currently undergoing clinical evaluation for autoimmune and oncology indications.
| Molecular Weight | 411.46 |
| Formula | C23H21N7O |
| CAS Number | 1229208-44-9 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Anjali Cremer, et al. Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia
[3] Chen Qu, et al. Tyrosine kinase SYK is a potential therapeutic target for liver fibrosis
| Related Syk Products |
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GSK143 is an orally active and highly selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.5. |
| PRT062607
PRT062607(P505-15; PRT-2607; BIIB-057) is a highly specific and potent inhibitor of Syk with IC50 of 1-2 nM; >80-fold selective for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70. |
| GSK143 dihydrochloride
GSK143 dihydrochloride is an orally active and highly selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.5. |
| Syk Kinase Peptide Substrate
Syk Kinase Peptide Substrate is a Syk kinase peptide substrate. |
| TOP1288
TOP1288 is an SRC/Syk/p38α inhibitor for studies related to ulcerative colitis. |
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