Syk Spleen tyrosine kinase

Cat.No.	Name	Information
M1767	R-406	R406 is an orally bioavailable and selective inhibitor of spleen tyrosine kinase (Syk) with the IC50 of 41nM and Ki value of 30 nM.
M5252	PRT-060318	PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase, with IC50 of 4 nM.
M21588	GSK2646264	GSK2646264 is a potent and selective splenic tyrosine kinase (Syk) inhibitor with a pIC50 value of 7.1. GSK2646264 also inhibited other kinases, with pIC50 values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3 for LCK, LRRK2, GSK3β, JAK2, VEGFR2, Aurora B and Aurora A, respectively. GSK2646264 penetrates into the epidermis and dermis of the skin.
M20799	GS-9876 (lanraplenib)	Lanraplenib (GS-9876, GS-SYK) is a potent, highly selective and orally active inhibitor of Spleen Tyrosine Kinase (SYK) with IC50 of 9.5 nM. Lanraplenib inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans.
M20797	SRX3207	SRX3207 is an orally active dual inhibitor of Syk-PI3K with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively. SRX3207 blocks tumor immunosuppression and increases anti-tumor immunity.
M20593	RO9021	RO9021 potently inhibits SYK kinase activity with an average IC50 of 5.6 nM and suppresses B-cell receptor signaling.
M20371	WAY-321341	WAY-321341 is a syk inhibitor
M20069	WAY-299721	WAY-299721 is a impede the interaction of Syk with its cellular partners while maintaining an active kinase protein (Syk inhibitor)
M14917	Fostamatinib disodium hexahydrate	Fostamatinib (R788) disodium hexahydrate is the oral prodrug of the active compound R406.
M14916	R406 besylate	R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a K_i of 30 nM, potently inhibits Syk kinase activity in vitro with an IC₅₀ of 41 nM, measured at an ATP concentration corresponding to its K_m value.
M14915	Cerdulatinib hydrochloride	Cerdulatinib hydrochloride (PRT062070) is a selective, oral active and reversible ATP-competitive inhibitor of dual SYK and JAK, with IC₅₀s of 32 nM, 0.5 nM, 12 nM, 6 nM and 8 nM for SYK and Tyk2, JAK1, 2, 3, respectively.
M10688	TAK-659	TAK-659 hydrochloride is a highly selective, reversible, orally potent dual inhibitor of SYK/FLT3 that acts on SYK and FLT3 IC50 The values are 3.2 nM and 4.6 nM, respectively. TAK-659 hydrochloride induces tumor cell death without acting on non-tumor cells, with potential to study chronic lymphocytic leukemia (CLL).
M9012	R112	R112 is an ATP-competitive inhibitor of Syk kinase with an IC50 of 226 nM.
M5252	PRT-060318	PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase, with IC50 of 4 nM.
M5247	BAY 61-3606 dihydrochloride	BAY-61-3606 is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM).
M2941	Piceatannol	Piceatannol, a natural stilbene, is a selective Syk inhibitor and ~10-fold selectivity versus Lyn.
M2729	GS-9973	GS-9973 is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM.
M2063	P505-15 hydrochloride	P505-15 (PRT062607) is a novel, highly selective inhibitor of Syk with IC50 value of 1-2 nM.
M1990	Fostamatinib (R788)	Fostamatinib (R788) is a spleen tyrosine kinase (Syk) inhibitor with IC50 of 41 nM.
M1847	Fostamatinib disodium	Fostamatinib disodium (R788, R-935788) is a potent, ATP-competitive and selective Syk (Spleen tyrosine kinase) inhibitor with IC50 of 41 nM.
M1767	R-406	R406 is an orally bioavailable and selective inhibitor of spleen tyrosine kinase (Syk) with the IC50 of 41nM and Ki value of 30 nM.

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Syk Spleen tyrosine kinase

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