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Syk Spleen tyrosine kinase

Inhibitors

Cat.No.  Name Information
M1767 R-406 R406 is an orally bioavailable and selective inhibitor of spleen tyrosine kinase (Syk) with the IC50 of 41nM and Ki value of 30 nM.
M14917 Fostamatinib disodium hexahydrate Fostamatinib (R788) disodium hexahydrate is the oral prodrug of the active compound R406.
M14916 R406 besylate R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value.
M14915 Cerdulatinib hydrochloride Cerdulatinib hydrochloride (PRT062070) is a selective, oral active and reversible ATP-competitive inhibitor of dual SYK and JAK, with IC50s of 32 nM, 0.5 nM, 12 nM, 6 nM and 8 nM for SYK and Tyk2, JAK1, 2, 3, respectively.
M10688 TAK-659 TAK-659 hydrochloride is a highly selective, reversible, orally potent dual inhibitor of SYK/FLT3 that acts on SYK and FLT3 IC50 The values are 3.2 nM and 4.6 nM, respectively. TAK-659 hydrochloride induces tumor cell death without acting on non-tumor cells, with potential to study chronic lymphocytic leukemia (CLL).
M9012 R112 R112 is an ATP-competitive inhibitor of Syk kinase with an IC50 of 226 nM.
M5252 PRT-060318 PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment.
M5247 BAY 61-3606 dihydrochloride BAY-61-3606 is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM).
M2941 Piceatannol Piceatannol, a natural stilbene, is a selective Syk inhibitor and ~10-fold selectivity versus Lyn.
M2729 GS-9973 GS-9973 is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM.
M2063 P505-15 hydrochloride P505-15 (PRT062607) is a novel, highly selective inhibitor of Syk with IC50 value of 1-2 nM.
M1990 R788 R788 (Fostamatinib) is a spleen tyrosine kinase (Syk) inhibitor with IC50 of 41 nM.
M1847 Fostamatinib disodium Fostamatinib disodium (R788, R-935788) is a potent, ATP-competitive and selective Syk (Spleen tyrosine kinase) inhibitor with IC50 of 41 nM.
M1767 R-406 R406 is an orally bioavailable and selective inhibitor of spleen tyrosine kinase (Syk) with the IC50 of 41nM and Ki value of 30 nM.



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