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R406 besylate

Cat. No. M14916
R406 besylate Structure
Synonym:

R406 benzenesulfonate; Tamatinib

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. R406 reduces immune complex-mediated inflammation. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 628.63
Formula C22H23FN6O5.C6H6O3S
CAS Number 841290-81-1
Purity >99%
Solubility DMSO ≥ 61 mg/mL
Storage 2-8°C, dry, sealed
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  Catalog
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Keywords: R406 besylate, R406 benzenesulfonate; Tamatinib supplier, Syk, inhibitors

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