Certificate of Analysis


Product Name: R406 besylate
Catalog Number: M14916
CAS Number: 841290-81-1

Physical and Chemical Properties
Formula: C22H23FN6O5.C6H6O3S
Molecular Weight: 628.63
Solubility: DMSO ≥ 61 mg/mL
Storage: 2-8°C, dry, sealed
Chemical Structure: R406 besylate Structure
Analytical Data
HPLC: Shows Min >99% purity
H-NMR: Consistent with structure
Product Information
Description: R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value.
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.