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Fostamatinib disodium hexahydrate

Cat. No. M14917
Fostamatinib disodium hexahydrate Structure

R788 disodium hexahydrate

Size Price Availability Quantity
5mg USD 100  USD100 In stock
10mg USD 160  USD160 In stock
50mg USD 450  USD450 In stock
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Quality Control & Documentation
Biological Activity

Fostamatinib (R788) disodium hexahydrate is the oral prodrug of the active compound R406. R406 is an orally available and competitive Syk/FLT3 inhibitor with a Ki of 30 nM and an IC50 of 41 nM. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM).

Chemical Information
Molecular Weight 732.51
CAS Number 914295-16-2
Solubility (25°C) DMSO 31.81 mg/mL
Water 2 mg/mL (ultrasonic and warming and heat to 60°C)
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Ali McBride, et al. Fostamatinib disodium hexahydrate: a novel treatment for adult immune thrombocytopenia

[2] Daniel A Hussar, et al. Prucalopride succinate, Fostamatinib disodium hexahydrate, Avatrombopag maleate, and Lusutrombopag

[3] David J Sweeny, et al. Metabolism of fostamatinib, the oral methylene phosphate prodrug of the spleen tyrosine kinase inhibitor R406 in humans: contribution of hepatic and gut bacterial processes to the overall biotransformation

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Keywords: Fostamatinib disodium hexahydrate, R788 disodium hexahydrate supplier, Syk, inhibitors, activators

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