| Cat.No. | Name | Information |
|---|---|---|
| M1767 | R-406 | R406 is an orally bioavailable and selective inhibitor of spleen tyrosine kinase (Syk) with the IC50 of 41nM and Ki value of 30 nM. |
| M5252 | PRT-060318 | PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase, with IC50 of 4 nM. |
| M1847 | Fostamatinib disodium | Fostamatinib disodium (R788, R-935788) is a potent, ATP-competitive and selective Syk (Spleen tyrosine kinase) inhibitor with IC50 of 41 nM. |
| M49937 | TOP1288 | TOP1288 is an SRC/Syk/p38α inhibitor for studies related to ulcerative colitis. |
| M49936 | R343 | R343 is an immunoglobulin E (IgE) as well as spleen tyrosine kinase (Syk) inhibitor for studies related to allergic asthma and non-small cell lung cancer. |
| M49935 | R333 | R333 is a JAK/SYK inhibitor that can be used in studies related to discoid lupus erythematosus (DLE). |
| M49934 | PRT2761 | PRT2761 is a spleen tyrosine kinase (Syk) inhibitor that may be used in studies related to allergic conjunctivitis. |
| M49933 | MK-8457 | MK-8457 is a splenic tyrosine kinase (Syk) inhibitor for studies related to the immune system and cardiovascular disease. |
| M49932 | IC265 | IC265 is a splenic tyrosine kinase (Syk) inhibitor that can be used in studies related to immune system and eye diseases. |
| M49930 | Lanraplenib succinate | Lanraplenib succinate is a potent, highly selective and orally active splenic tyrosine kinase (SYK) inhibitor and inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor with an IC50 value of 9.5 nM. |
| M49786 | Syk-IN-6 | Syk-IN-6 is an inhibitor of the lipid-SH2 domain interaction, control the cellular activity of kinases containing SH2 domain. |
| M49785 | SYK/JAK-IN-1 | SYK/JAK-IN-1 is dual SYK/JAK inhibitor with IC50s of <5 nM for SYK and JAK2, respectively. |
| M43533 | Syk-IN-7 | Syk-IN-7 is an inhibitor of spleen tyrosine kinase (SYK). |
| M43532 | Syk-IN-8 | Syk-IN-8 is a Syk inhibitor, with antiproliferative activity against multiple hematological tumour cells. |
| M43531 | ER-27319 | ER-27319, an acridone derivative, is a potent and selective SYK inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. |
| M39850 | Dehydroabietinol | Dehydroabietinol is an abietane diterpenoid. Dehydroabietinol has kinase inhibition activity for spleen tyrosine kinase (SYK) with an IC50 value of 46.4 μM. Dehydroabietinol can be used for the research of immune-mediated disease. |
| M29129 | Cevidoplenib dimesylate | Cevidoplenib is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities. |
| M28818 | Cevidoplenib | Cevidoplenib is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities. |
| M28531 | Syk-IN-1 | Syk-IN-1 (compound 4) is a potent Syk inhibitor, with an IC50 of 35 nM. |
| M28411 | TAS05567 | TAS05567 is a potent, highly selective, ATP-competitive and orally active Syk inhibitor with an IC50 of 0.37 nM. In a panel of 192 kinases, TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, JAK2, KDR and RET with IC50s of 10 nM, 4.8 nM, 600 nM and 29 nM, respectively). TAS05567 can be used for humoral immune-mediated inflammatory conditions such as autoimmune and allergic diseases. |
| M28158 | TAK-659 | TAK-659 is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL). |
| M21588 | GSK2646264 | GSK2646264 is a potent and selective splenic tyrosine kinase (Syk) inhibitor with a pIC50 value of 7.1. GSK2646264 also inhibited other kinases, with pIC50 values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3 for LCK, LRRK2, GSK3β, JAK2, VEGFR2, Aurora B and Aurora A, respectively. GSK2646264 penetrates into the epidermis and dermis of the skin. |
| M20593 | RO9021 | RO9021 potently inhibits SYK kinase activity with an average IC50 of 5.6 nM and suppresses B-cell receptor signaling. |
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