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Cevidoplenib

Cat. No. M28818

All AbMole products are for research use only, cannot be used for human consumption.

Cevidoplenib Structure
Synonym:

SKI-O-703

Price and Availability

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Quality Control & Documentation
Biological Activity

Cevidoplenib is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities.

Chemical Information
Molecular Weight 473.53
Formula C25H27N7O3
CAS Number 1703788-21-9
Form Solid
Solubility (25°C) DMSO 50 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Somi Cho, et al. Clin Exp Immunol. A novel selective spleen tyrosine kinase inhibitor SKI-O-703 (cevidoplenib) ameliorates lupus nephritis and serum-induced arthritis in murine models

[2] Nichola Cooper, et al. Platelets. Recent advances in understanding spleen tyrosine kinase (SYK) in human biology and disease, with a focus on fostamatinib

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PRT062607(P505-15; PRT-2607; BIIB-057) is a highly specific and potent inhibitor of Syk with IC50 of 1-2 nM; >80-fold selective for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70.

GSK143 dihydrochloride 

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Syk Kinase Peptide Substrate

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  Catalog
Abmole Inhibitor Catalog




Keywords: Cevidoplenib, SKI-O-703 supplier, Syk, inhibitors, activators

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