All AbMole products are for research use only, cannot be used for human consumption.
Sovalleplenib is a potent, orally active, selective Syk inhibitor with an IC50 of 25 nM.Sovalleplenib inhibits tyrosine kinase-dependent Fcγ receptor-mediated phagocytosis by macrophages, which in turn reduces phagocytotic destruction of platelets, as well as reduces production of antiplatelet antibodies by B-cells.Sovalleplenib has antitumor activity in immune thrombocytopenia (ITP).
| Molecular Weight | 482.60 |
| Formula | C24H30N6O3S |
| CAS Number | 1415792-84-5 |
| Form | Solid |
| Solubility (25°C) | DMSO 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Syk Products |
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| GSK143
GSK143 is an orally active and highly selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.5. |
| PRT062607
PRT062607(P505-15; PRT-2607; BIIB-057) is a highly specific and potent inhibitor of Syk with IC50 of 1-2 nM; >80-fold selective for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70. |
| GSK143 dihydrochloride
GSK143 dihydrochloride is an orally active and highly selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.5. |
| Syk Kinase Peptide Substrate
Syk Kinase Peptide Substrate is a Syk kinase peptide substrate. |
| TOP1288
TOP1288 is an SRC/Syk/p38α inhibitor for studies related to ulcerative colitis. |
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Products are for research use only. Not for human use. We do not sell to patients.
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