About 1 result found for searched term "1415792-84-5" (0.12 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M49931 | Sovleplenib | Syk |
| HMPL-523 | ||
| Sovalleplenib is a potent, orally active, selective Syk inhibitor with an IC50 of 25 nM.Sovalleplenib inhibits tyrosine kinase-dependent Fcγ receptor-mediated phagocytosis by macrophages, which in turn reduces phagocytotic destruction of platelets, as well as reduces production of antiplatelet antibodies by B-cells.Sovalleplenib has antitumor activity in immune thrombocytopenia (ITP). | ||
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