About 31 results found for searched term "Rac1-IN-3" (0.079 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M41932 | Rac1-IN-3 | Ras |
| Rac1-IN-3 is a Rac1 inhibitor with an IC50 of 46.1 μM. | ||
| M25536 | Recombinant Human CXCL13/BCA-1 (E. coli) | Cytokines and Growth Factors |
| CXC chemokine BLC; Small-inducible cytokine B13 | ||
| CXCL13, also known as B-lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. Recombinant human CXCL13 is a single non-glycosylated polypeptide chain containing 87 amino acids and mature human BCA-1 shares 64 % amino acid sequence similarity with the murine protein and 23–34 % amino acid sequence identity with other known CXC chemokines. Determined by a chemotaxis bioassay using human B cells, the biological activity is in a concentration range of 1.0-10 ng/ml. | ||
| M2663 | EHop-016 | GTPase |
| EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1, equally potent inhibition for Rac3. | ||
| M2756 | Histamine dihydrochloride | Histamine Receptor |
| Histamine 2HCl is an endogenous ligand for the histamine receptor, which can cause allergic reactions by interacting with H1 receptors, promote acid secretion by interacting with H2 receptors, as well as inhibit histamine release and modulate immune responses by interacting with H3 receptors and H4 receptors. It can be used in studies related to allergy, hyperacidity, sleep disorders, asthma and many other diseases. | ||
| M2800 | KY02111 | Others |
| KY02111 is a widely used small molecule that boosts cardiomyogenesis. Chemical genetics of KY02111 identified squalene synthase (SQS) as a molecular target of KY02111. By disrupting the interaction of SQS with cardiac ER-membrane protein TMEM43, KY02111 impairs TGFβ/SMAD signaling and recapitulates the clinical mutation of TMEM43 that causes an inherited heart disease. | ||
| M11542 | Ochromycinone | STAT |
| (Rac)-STA-21；STA 21 | ||
| Ochromycinone ((RAC-STA-21) is a natural antibiotic and a selective inhibitor of STAT3. Ochromycinone can inhibit STAT3 DNA binding activity and STAT3 dimerization. Ochromycinone has anticancer and antibacterial activities. | ||
| M4092 | Ginsenoside-Rk1 | NF-κB |
| Ginsenoside Rk1 is a high-temperature processed extract of ginseng. Ginsenoside Rk1 has anti-inflammatory effects and inhibits Jak2/Stat3 signaling pathway and NF-κB activation. | ||
| M4117 | Hederacolchiside-A1 | PI3K |
| Hederacolchiside A1, isolated from Pulsatilla pulsatilla, induces apoptosis by regulating the PI3K/Akt/mTOR signaling pathway, thereby inhibiting the proliferation of tumor cells. Hederacolchiside A1 has anti-schistosomiasis activity and affects parasite viability in vivo and in vitro. | ||
| M4357 | 3-Isomangostin | DNA/RNA Synthesis |
| 3 - Isomangostin from Garciniamangostana. L. Extracted from shell, 3-isomangostin is an effective MutT homolog 1 (MTH1) inhibitor with IC50 value of 52 nM. 3-Isomangostin can be used to develop anticancer agents. | ||
| M4520 | (+)-Corydaline | AChR/AChE |
| (+)-Corydaline; Corydalin | ||
| Corydaline ((+) -corydaline) is an isoquinoline alkaloid extracted from Corydalis Yanhusuo. It is an inhibitor of AChE with IC50 of 226 µM. Corydaline is a μ-opioid receptor agonist (Ki = 1.23 µM) that inhibits the replication of enterovirus 71 (EV71) (IC50 = 25.23 µM). Corydaline has anti-angiogenesis, anti-allergy, gastric emptying and anti-nociception effects. | ||
| M4621 | Garcinone-C | ATM/ATR |
| Garcinone C is a xanthone derivative, a natural compound extracted from Garcinia oblongifolia Champ. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while effectively inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, CDC2, Stat3 and CDK7. | ||
| M5027 | CPI-169 racemate | EZH2 |
| CPI-169 racemate is the racemate form of CPI-169, which is a novel and potent EZH2 inhibitor with IC50 <1 nM(inhibition of the catalytic activity of PRC2); decreases cellular levels of H3K27me3 with an EC50 of 70 nM, and triggers cell cycle arrest and apoptosis in a variety of cell lines. | ||
| M5692 | Histamine | Histamine Receptor |
| Ergamine | ||
| Histamine is an endogenous ligand for histamine receptors, which can cause allergic reactions by interacting with H1 receptors, promote acid secretion by interacting with H2 receptors, as well as inhibit histamine release and modulate immune responses by interacting with H3 receptors and H4 receptors. It can be used in studies related to allergy, hyperacidity, sleep disorders, asthma and many other diseases. | ||
| M6528 | BRACO-19 trihydrochloride | DNA/RNA Synthesis |
| BRACO-19 trihydrochloride is a potent telomerase/telomere inhibitor, preventing the capping and catalytic action of telomerase. Braco-19 acts as G-quadruplex (GQ) binding ligand, stabilizing G-quadruplexes formation at the 3V telomeric DNA overhang and produce rapid senescence or selective cell death. | ||
| M6704 | EHT 1864 2HCl | Ras |
| EHT 1864 is a potent inhibitor of Rac family GTPases. EHT 1864 directly binds and impairs the ability of this small GTPase to engage critical downstream effectors required for growth transformation. The Kd values are 40, 50, 60, and 230 nM for Rac1, Rac1b, Rac2 and Rac3, respectively. | ||
| M7177 | Quinine hydrochloride | Potassium Channel |
| Quinine hydrochloride is the hydrochloride form of Quinine, an alkaloid extracted from the bark of the cinchona tree, with antimalarial and antitumor activities, and an IC50 value of 60 ng/mL against P. falciparum strains passou and 107.8 ng/mL against P. falciparum strain 3CD7, respectively, and an inhibitor of potassium channels. Quinine hydrochloride is also a potassium channel inhibitor that inhibits voltage pulse-induced MT mSlo3 (KCa5.1) channel +100 mV currents, with an IC50 value of 169 μM. In addition, Quinine hydrochloride binds to purine nucleoside phosphorylase (PfNP) and PfNP with low nanomolar affinity. nucleoside phosphorylase (PfPNP) with low nanomolar affinity. | ||
| M7790 | Emodin | Casein Kinase |
| Frangula emodin | ||
| Emodin is an anti-SARS-CoV compound that blocks the interaction between the SARS-coronavirus spike protein and angiotensin converting enzyme 2 (ACE2). Emodin inhibited casein kinase 2 (CK2) and 11β-HSD1. Emodin can also induce necrotic apoptosis of glioma U251 cells and inhibit U251 cell proliferation by targeting the TNF/RIPK1/RIPK3 signaling pathway. | ||
| M8504 | EPPTB | TAAR |
| EPPTB is a potent, selective trace amine-associated receptor 1 (TAAR1) antagonist with an IC50 value of 28 nM for mouse TAAR1. EPPTB is less selective in rats and humans, with IC50 values of 4539 nM and 7487 nM, respectively. | ||
| M8529 | A-366 | Histone Methyltransferase |
| A366 | ||
| A-366 is a potent and highly selective peptide-competitive inhibitor of histone methyltransferase G9a, with IC50s of 3.3 nM and 38 nM for G9a and GLP, respectively, and is more than 1,000-fold selective for G9a and GLP over 21 other methyltransferases. A-366 is also a potent inhibitor of Spindlin1-H3K4me3 interaction (IC50=182.6 nM).A-366 shows high affinity for human H3R (Ki=17 nM) and exhibits subtype selectivity between subpopulations of the histaminergic and dopaminergic receptor families. It can be used for induction and maintenance of pluripotent stem cells in mice. | ||
| M8733 | K67 | Keap1-Nrf2 |
| K-67 | ||
| K67 is a specific inhibitor against the interaction between KEAP1 (Kelch-like ECH-associated protein 1) DC (double glycine repeat and C-terminal region) domain and S349-phosphorylated (human Ser349, mouse Ser351) KIR (Keap1-interacting region) of p62/SQSTM1, thereby preventing phospho-p62 from blocking KEAP1-DC and NRF2 (nuclear factor erythroid 2-related factor 2) DLGex motif association. | ||
| M9298 | AX-024 hydrochloride | Immunology/Inflammation |
| AX-024 HCl | ||
| Ax-024 Hydrochloride is orally available, the first tCR-NCK interaction inhibitor that selectively inhibits TCR-induced T cell activation with an IC50 value of 1 nM. Ax-024 Hydrochloride regulates cellular signaling by targeting the SH3 domain. Ax-024 Hydrochloride has the characteristics of low toxicity, high efficiency and high selectivity. | ||
| M10283 | AZD-5991 Racemate | Bcl-2 |
| AZD-5991 Racemate is a Mcl-1 inhibitor with an IC50 of <3 nM in FRET assay. | ||
| M10327 | Zotiraciclib | CDK |
| TG02; SB1317 | ||
| Zotiraciclib (TG02, SB1317) is an orally bioavailable, brain penetrant multi-kinase inhibitor of CDK2, JAK2, and FLT3 with IC50 values of 13, 73, and 56 nM, respectively. | ||
| M10683 | IMB-301 | HIV Protease |
| IMB-301 is a specific HIV-1 replication inhibitor that binds to hA3G (human APOBEC3G), interrupts the hA3G-Vif interaction and inhibits Vif-mediated degradation of hA3G. IMB-301 inhibits the replication of HIV-1 in H9 cells (IC50=8.63 uM). Human APOBEC3G is a restriction factor that inhibits human immunodeficiency 1 virus (HIV-1) replication. | ||
| M10863 | NCGC00378430 | Others |
| NCGC00378430 is a potent inhibitor of the SIX1/EYA2 interaction. NCGC00378430 partially reverses SIX1 overexpression-mediated transcription and metabolic profiling, and reverses SIX1-induced TGF-β signaling and epithelial-interstitial transformation (EMT). NCGC00378430 inhibits SIX1-mediated breast cancer metastasis in mouse models. | ||
| M10886 | Samuraciclib hydrochloride | CDK |
| Samuraciclib (ICEC0942, CT7001) is a novel oral CDK7 inhibitor with an IC50 of 40 nM. It has IC50 values for other CDK proteins such as CDK1, CDK2, CDK5 and CDK9 as 45, 15, 230 and 30 times higher than that of CDK7 IC50, respectively. ICEC0942 (CT7001) promotes cell cycle blocking and apoptosis. | ||
| M10931 | KEA1-97 | Caspase |
| KEA197 | ||
| KEA1-97 is a selective Thioredoxin-caspase 3 interaction disruptor (IC50=10 μM). KEA1-97 disrupts the interaction of thioredoxin with caspase 3, activates caspases, and induces apoptosis without affecting thioredoxin activity. | ||
| M11308 | E6446 | TLR |
| E-6446 | ||
| E6446 is an inhibitor of Toll-like receptor (TLR) 7 and 9 signaling in a variety of human and mouse cell types and inhibits DNA-TLR9 interactions in vitro. E6446 is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. | ||
| M13383 | (Rac)-Indoximod | IDO |
| 1-Methyl-DL-tryptophan; (Rac)-NLG-8189 | ||
| (Rac)-Indoximod(1-methyl-DL-tryptophan) is an indoleamine 2, 3-dioxygenase (IDO) inhibitor. | ||
| M13814 | O6BTG-octylglucoside | DNA Methyltransferase |
| Glucose-conjugated MGMT inhibitor | ||
| O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor, with IC50s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells. | ||
| M15034 | Recombinant Human CD25/IL-2Rα Fc Chimera (HEK 293) | Cytokines and Growth Factors |
| CD25 antigen; CD25; IDDM10 | ||
| The IL-2 receptor system consists of three non-covalently linked subunits termed IL-2Rα, IL-2Rβ, and IL-2Rγ. The IL-2Rα is a type I transmembrane protein consisting of a 219 amino acid (a.a.) extracellular domain, a 19 a.a. transmembrane domain and a 13 a.a. intracellular domain, which is not involved in the transduction of IL-2 signal. | ||
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